CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042760
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein CASC5 
Protein Synonyms/Alias
  
Gene Name
 CASC5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26NFELSQRKSLGTPTVubiquitination[1, 2]
83ADNMELSKSATCKNIubiquitination[1, 2]
88LSKSATCKNIKDVQSubiquitination[1]
91SATCKNIKDVQSPGFubiquitination[1, 3]
106LNEPLSSKSQRRKSLubiquitination[1, 2, 3, 4]
184HTTALECKTLLPNEIubiquitination[1, 2]
233KILEENPKFGIGKGKacetylation[5]
233KILEENPKFGIGKGKubiquitination[1, 2, 4]
238NPKFGIGKGKNLGVSubiquitination[1]
240KFGIGKGKNLGVSFPubiquitination[1, 2]
248NLGVSFPKDNSCVQEubiquitination[1, 2]
259CVQEIAEKQALAVGNubiquitination[1, 2, 6]
275IVLHTEQKQQLFAATubiquitination[1]
291RTTNEIIKFHSAAMDubiquitination[1, 2]
300HSAAMDEKVIGKVVDubiquitination[1, 2]
304MDEKVIGKVVDQACTubiquitination[1, 2]
314DQACTLEKAQVESCQubiquitination[1, 2]
432DCVITLHKDQDLIKDubiquitination[1, 2]
438HKDQDLIKDPRNLLAubiquitination[1, 2, 4]
460QDLGEMTKLNSKRVSubiquitination[1, 2, 4]
469NSKRVSFKLPKDQMKubiquitination[2]
476KLPKDQMKVYVDDIYubiquitination[1, 2]
500DQPPLPKKGQSSINKubiquitination[1, 2]
507KGQSSINKEEVILSKubiquitination[1, 2]
514KEEVILSKAGNKSLNubiquitination[4]
518ILSKAGNKSLNIIENubiquitination[2]
534SAPICENKPKILNSEubiquitination[1, 2]
536PICENKPKILNSEEWubiquitination[1, 2]
550WFAAACKKELKENIQubiquitination[1, 2]
553AACKKELKENIQTTNubiquitination[1]
603VPCFHSIKPNLNNLNubiquitination[1]
689PKTVFKDKVRRCSLGmethylation[7]
737ETQPVSSKDSGIGSVubiquitination[1, 2]
789ALIETYQKEISPYENubiquitination[1, 2]
797EISPYENKMGKTCNSubiquitination[2]
849HTEEDIDKSANSVLIubiquitination[1]
874SSSLDSIKADGTSLDubiquitination[1, 2]
995KLLVDINKNLWEKMRubiquitination[1, 2]
1000INKNLWEKMRHCSDKubiquitination[1]
1102SEMRAAEKELEQLKTubiquitination[1]
1137AQIDFMQKQRNRTEEubiquitination[1]
1266GEEIEYLKRWGPNYNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1361 AA 
Protein Sequence
XSHTVFIDYQ EKERTDRPNF ELSQRKSLGT PTVICTPTEE SVFFPGNGES DRLVANDSQL 60
TPLEEWSNNR GPVEVADNME LSKSATCKNI KDVQSPGFLN EPLSSKSQRR KSLKLKNDKT 120
IVFSENHKND MDITQSCMVE IDNESALEDK EDFHLAGASK TILYSCGQDD MEITRSHTTA 180
LECKTLLPNE IAIRPMDKTV LFTDNYSDLE VTDSHTVFID CQATEKILEE NPKFGIGKGK 240
NLGVSFPKDN SCVQEIAEKQ ALAVGNKIVL HTEQKQQLFA ATNRTTNEII KFHSAAMDEK 300
VIGKVVDQAC TLEKAQVESC QLNNRDRRNV DFTSSHATAV CGSSDNYSCL PNVISCTDNL 360
EGSAMLLCDK DEEKANYCPV QNDLAYANDF ASEYYLESEG QPLSAPCPLL EKEEVIQTST 420
KGQLDCVITL HKDQDLIKDP RNLLANQTLV YSQDLGEMTK LNSKRVSFKL PKDQMKVYVD 480
DIYVIPQPHF STDQPPLPKK GQSSINKEEV ILSKAGNKSL NIIENSSAPI CENKPKILNS 540
EEWFAAACKK ELKENIQTTN YNTALDFHSN SDVTKQVIQT HVNAGEAPDP VITSNVPCFH 600
SIKPNLNNLN GKTGEFLAFQ TVHLPPLPEQ LLELGNKAHN DMHIVQATEI HNINIISSNA 660
KDSRDEENKK SHNGAETTSL PPKTVFKDKV RRCSLGIFLP RLPNKRNCSV TGIDDLEQIP 720
ADTTDINHLE TQPVSSKDSG IGSVAGKLNL SPSQYINEEN LPVYPDEINS SDSINIETEE 780
KALIETYQKE ISPYENKMGK TCNSQKRTWV QEEEDIHKEK KIRKNEIKFS DTTQDREIFD 840
HHTEEDIDKS ANSVLIKNLS RTPSSCSSSL DSIKADGTSL DFSTYRSSQM ESQFLRDTIC 900
EESLREKLQD GRITIREFFI LLQVHILIQK PRQSNLPGNF TVNTPPTPED LMLSQYVYRP 960
KIQIYREDCE ARRQKIEELK LSASNQDKLL VDINKNLWEK MRHCSDKELK AFGIYLNKIK 1020
SCFTKMTKVF THQGKVALYG KLVQSAQNER EKLQIKIDEM DKILKKIDNC LTEMETETKN 1080
LEDEEKNNPV EEWDSEMRAA EKELEQLKTE EEELQRNLLE LEVQKEQTLA QIDFMQKQRN 1140
RTEELLDQLS LSEWDVVEWS DDQAVFTFVY DTIQLTITFE ESVVGFPFLD KRYRKIVDVN 1200
FQSLLDEDQA PPSSLLVHKL IFQYVEEKES WKKTCTTQHQ LPKMLEEFSL VVHHCRLLGE 1260
EIEYLKRWGP NYNLMNIDIN NNELRLLFSS SAAFAKFEIT LFLSAYYPSV PLPSTIQNHV 1320
GNTSQDDIAT ILSKVPLENN YLKNVVKQIY QDLFQDCHFY H 1361 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS