Tag | Content |
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CPLM ID | CPLM-008447 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lumican |
Protein Synonyms/Alias | Keratan sulfate proteoglycan lumican; KSPG lumican |
Gene Name | Lum |
Gene Synonyms/Alias | Lcn; Ldc |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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69 | PMVPPGIKYLYLRNN | acetylation | [1] | 114 | IKGKVFSKLKQLKKL | acetylation | [1] | 148 | DLQLANNKISKLGSF | acetylation | [1] | 181 | EAVSASLKGLKSLEY | acetylation | [1] | 184 | SASLKGLKSLEYLDL | acetylation | [1] | 285 | NYYLEVNKLEKFDVK | acetylation | [1] | 288 | LEVNKLEKFDVKSFC | acetylation | [1] | 305 | LGPLSYSKIKHLRLD | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | |
Sequence Annotation | DOMAIN 28 66 LRRNT. REPEAT 67 88 LRR 1. REPEAT 91 114 LRR 2. REPEAT 117 137 LRR 3. REPEAT 138 159 LRR 4. REPEAT 160 181 LRR 5. REPEAT 185 205 LRR 6. REPEAT 206 227 LRR 7. REPEAT 230 250 LRR 8. REPEAT 255 276 LRR 9. REPEAT 277 296 LRR 10. REPEAT 305 326 LRR 11. MOD_RES 19 19 Pyrrolidone carboxylic acid (By MOD_RES 20 20 Sulfotyrosine (By similarity). MOD_RES 21 21 Sulfotyrosine (By similarity). MOD_RES 23 23 Sulfotyrosine (By similarity). MOD_RES 30 30 Sulfotyrosine (By similarity). CARBOHYD 88 88 N-linked (GlcNAc...) (keratan sulfate) CARBOHYD 127 127 N-linked (GlcNAc...) (keratan sulfate) CARBOHYD 160 160 N-linked (GlcNAc...) (keratan sulfate) CARBOHYD 252 252 N-linked (GlcNAc...) (keratan sulfate) DISULFID 295 328 By similarity. |
Keyword | Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Leucine-rich repeat; Proteoglycan; Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal; Sulfation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 338 AA |
Protein Sequence | MNVCTFTLVL ALVGSVSGQY YDYDAPLFMY GELSPNCAPE CNCPHSYPTA MYCDDLKLKS 60 VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN LLENSKIKGK VFSKLKQLKK 120 LHINYNNLTE SVGPLPKSLQ DLQLANNKIS KLGSFDGLVN LTFIYLQHNQ LKEEAVSASL 180 KGLKSLEYLD LSFNQMSKLP AGLPTSLLTL YLDNNKITNI PDEYFNRFTG LQYLRLSHNE 240 LADSGVPGNS FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNKLEKFD VKSFCKILGP 300 LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN 338 |
Gene Ontology | GO:0005615; C:extracellular space; IEA:Compara. GO:0005583; C:fibrillar collagen; IEA:Compara. GO:0005578; C:proteinaceous extracellular matrix; IDA:RGD. GO:0051216; P:cartilage development; IEP:RGD. GO:0030199; P:collagen fibril organization; IEA:InterPro. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0070848; P:response to growth factor stimulus; IEP:RGD. GO:0014070; P:response to organic cyclic compound; IEP:RGD. GO:0007601; P:visual perception; IEA:InterPro. |
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SMART | |
PROSITE | |
PRINTS | |