UniProt Accession

 ELP6_HUMAN; Q0PNE2; Q9BW57; Q9NXJ3 

Genbank Protein ID

 DQ787088; AK000218; BC000623; BC014204 

Genbank Nucleotide ID

 ABG79574.1; BAA91017.1; AAH00623.1; AAH14204.1 

Protein Name

 Elongator complex protein 6 

Protein Synonyms/Alias

 Angiotonin-transactivated protein 1; Protein TMEM103 

Gene Name

 ELP6 

Gene Synonyms/Alias

 ATP1; C3orf75; TMEM103 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	EANAGNLKPLFEFVR	ubiquitination	[1, 2, 3]
127	EFVREALKPVDSGEA	ubiquitination	[2]
248	QSFTYQYKIQDKSVS	ubiquitination	[1, 2, 3]
259	KSVSFFAKGMSPAVL	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 266 AA 

Protein Sequence

Gene Ontology

 GO:0033588; C:Elongator holoenzyme complex; IDA:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR018627; UPF0405. 

Pfam

 PF09807; DUF2348 

SMART

  

PROSITE

  

PRINTS