CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myocyte-specific enhancer factor 2A 
Protein Synonyms/Alias
  
Gene Name
 MEF2A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
127EDSDFIFKRGPPGLPubiquitination[1]
247TGANSLGKVMPTKSPacetylation[2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 506 AA 
Protein Sequence
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST 60
DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCESPD ADDYFEHSPL SEDRFSKLNE 120
DSDFIFKRGP PGLPPQNFSM SVTVPVTSPN ALSYTNPGSS LVSPSLAASS TLTDSSMLSP 180
PQTTLHRNVS PGAPQRPPST GNAGGMLSTT DLTVPNGAGS SPVGNGFVNS RASPNLIGAT 240
GANSLGKVMP TKSPPPPGGG NLGMNSRKPD LRVVIPPSSK GMMPPLYLKR QLNTNNTQRI 300
SSSQATQPLA TPVVSVTTPS LPPQGLVYSA MPTAYNTDYS LTSADLSALQ GFNSPGMLSL 360
GQVSAWQQHH LGQAALSSLV AGGQLSQGSN LSINTNQNIS IKSEPISPPR DRMTPSGFQQ 420
QQQQQQQQQP PPPPQPQPQP PQPQPRQEMG RSPVDSLSSS SSSYDGSDRE DPRGDFHSPI 480
VLGRPPNTED RESPSVKRMR MDAWVT 506 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR022102; HJURP_C.
 IPR002100; TF_MADSbox. 
Pfam
 PF12347; HJURP_C
 PF00319; SRF-TF 
SMART
 SM00432; MADS 
PROSITE
 PS00350; MADS_BOX_1
 PS50066; MADS_BOX_2 
PRINTS
 PR00404; MADSDOMAIN.