UniProt Accession

 TFDP_DROME; Q24318; B8A3X4; O17472; O44080; Q86PE0; Q8ML56; Q9V6M0 

Genbank Protein ID

 AE013599; AE013599; AY069526; BT003183; BT056266; X79708; AF011362 

Genbank Nucleotide ID

 AAF58403.1; AAM68602.1; AAL39671.1; AAO24938.1; ACL68713.1; CAA56147.2; AAB87765.1 

Protein Name

 Transcription factor Dp 

Protein Synonyms/Alias

  

Gene Name

 Dp 

Gene Synonyms/Alias

 CG4654 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
30	GQISKMLKPAQNKSE	acetylation	[1]
42	KSEMEGGKPVAVVYA	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes. Can stimulate E2F- dependent transcription. 

Sequence Annotation

 MOD_RES 398 398 Phosphoserine.  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 445 AA 

Protein Sequence

Gene Ontology

 GO:0031523; C:Myb complex; IDA:FlyBase.
 GO:0035189; C:Rb-E2F complex; IDA:FlyBase.
 GO:0003677; F:DNA binding; IDA:FlyBase.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008069; P:dorsal/ventral axis specification, ovarian follicular epithelium; IMP:FlyBase.
 GO:0007307; P:eggshell chorion gene amplification; TAS:FlyBase.
 GO:0007113; P:endomitotic cell cycle; TAS:FlyBase.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:FlyBase.
 GO:0045476; P:nurse cell apoptotic process; TAS:FlyBase.
 GO:0010628; P:positive regulation of gene expression; IMP:FlyBase.
 GO:0045850; P:positive regulation of nurse cell apoptotic process; IMP:FlyBase.
 GO:0051726; P:regulation of cell cycle; IMP:FlyBase.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IPI:GOC.
 GO:0006366; P:transcription from RNA polymerase II promoter; IPI:GOC. 

Interpro

 IPR003316; E2F_TDP.
 IPR014889; Transc_factor_DP_C.
 IPR016556; Transcription_factor_DP_subgr.
 IPR015648; Transcrpt_fac_DP.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF08781; DP
 PF02319; E2F_TDP 

SMART

  

PROSITE

  

PRINTS