| Tag | Content |
|---|
| CPLM ID | CPLM-012793 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Hsp90 co-chaperone Cdc37 |
Protein Synonyms/Alias | Hsp90 chaperone protein kinase-targeting subunit; Protein enhancer of sevenless 3B |
Gene Name | Cdc37 |
Gene Synonyms/Alias | E(sev)3B; CG12019 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 115 | WNVDTISKPGFEKTV | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. |
Sequence Annotation | MOD_RES 13 13 Phosphoserine.
MOD_RES 19 19 Phosphothreonine.
MOD_RES 296 296 Phosphoserine.
MOD_RES 355 355 Phosphoserine. |
Keyword | Cell cycle; Cell division; Chaperone; Chromosome partition; Complete proteome; Cytoplasm; Developmental protein; Meiosis; Mitosis; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 389 AA |
Protein Sequence | MVDYSKWKNI EISDDEDDTH PNIDTPSLFR WRHQARVERM AEMDHEKDEL KKKRQSYQAR 60
LMDVKERISK KDGDEEALKK ELEKIEAEGK ELDRIESEMI KKEKKTPWNV DTISKPGFEK 120
TVINKKAGRK PDENLSEEER EQRMKQFVKE NEKLCQQYGM LRKYDDSKRF LQEHLHLVGE 180
ETANYLVIWS INLEMEEKHE LMAHVAHQCI CMQYILELAK QLDVDPRACV SSFFSKIQHC 240
HPEYRAQFDS EIEGFKGRIQ KRAQEKIQEA IAQAEEEERK ERLGPGGLDP ADVFESLPDE 300
LKACFESRDV ELLQKTIAAM PVDVAKLHMK RCVDSGLWVP NAADLEGDKK EEDDSDDVAG 360
GEEKTDDAKS ESAAKEEPIY TGVSTEDVD 389 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0051087; F:chaperone binding; NAS:UniProtKB. GO:0030296; F:protein tyrosine kinase activator activity; NAS:UniProtKB. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW. GO:0007243; P:intracellular protein kinase cascade; NAS:UniProtKB. GO:0007126; P:meiosis; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0022008; P:neurogenesis; IMP:FlyBase. |
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