CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025770
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MKIAA4106 protein 
Protein Synonyms/Alias
  
Gene Name
 Cul2 
Gene Synonyms/Alias
 mKIAA4106 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
19DFDETWNKLLTTIKAubiquitination[1]
117YLNTQYIKKNKLTEAubiquitination[1]
241NCSQYMEKVLGRLKDubiquitination[1]
294SIIQQERKNDMANMYubiquitination[1]
385VVNYREPKSVCKAPEubiquitination[1]
396KAPELLAKYCDNLLKubiquitination[1]
431VFKYIDDKDVFQKFYubiquitination[1]
436DDKDVFQKFYARMLAubiquitination[1]
611DSTQMNEKELTKTIKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 748 AA 
Protein Sequence
TCTMSLKPRV VDFDETWNKL LTTIKAVVML EYVERATWND RFSDIYALCV AYPEPLGERL 60
YAETKIFLES HVRHLYKRVL ESEEQVLVMY HRYWEEYSKG ADYMDCLYRY LNTQYIKKNK 120
LTEADIQYGY GGVDMNEPLM EIGELALDMW RKLMVEPLQN ILIRMLLREI KNDRGGEDPN 180
QKVIHGVINS FVHVEQYKKK FPLKFYQGIF VSPFLTETGE YYKQEASNLL QESNCSQYME 240
KVLGRLKDEE IRCRKYLHPS SYTKVIHECQ QRMVADHLQF LHSECHSIIQ QERKNDMANM 300
YVLLRAVSSG LPHMIEELQK HIHDEGLRAT SNLTQEHMPT LFVESVLEVH GKFVQLINTV 360
LNGDQHFMSA LDKALTSVVN YREPKSVCKA PELLAKYCDN LLKKSAKGMT ENEVEDKLTS 420
FITVFKYIDD KDVFQKFYAR MLAKRLIHGL SMSMDSEEAM INKLKQACGY EFTSKLHRMY 480
TDMSVSADLN NKFNNFIRNQ DTVIDLGISF QIYVLQAGAW PLTQAPSSTF AIPQELEKSV 540
QMFELFYSQH FSGRKLTWLH YLCTGEVKMN YLGKPYVAMV TTYQMAVLLA FNNSETVSYK 600
ELQDSTQMNE KELTKTIKSL LDVKMINHDS EKEDIDAESS FSLNMSFSSK RTKFKITTSM 660
QKDTPQELEQ TRSAVDEDRK MYLQAAIVRI MKARKVLRHN ALIQEVISQS RARFNPSISM 720
IKKCIEVLID KQYIERSQAS ADEYSYVA 748 
Gene Ontology
 GO:0031462; C:Cul2-RING ubiquitin ligase complex; IEA:Compara.
 GO:0030163; P:protein catabolic process; IMP:MGI.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR016157; Cullin_CS.
 IPR016158; Cullin_homology.
 IPR001373; Cullin_N.
 IPR019559; Cullin_neddylation_domain.
 IPR016159; Cullin_repeat-like_dom.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00888; Cullin
 PF10557; Cullin_Nedd8 
SMART
 SM00182; CULLIN
 SM00884; Cullin_Nedd8 
PROSITE
 PS01256; CULLIN_1
 PS50069; CULLIN_2 
PRINTS