UniProt Accession

 MSCL_ECOLI; P0A742; P23867; Q2M6V5 

Genbank Protein ID

 U08371; L29458; U18997; U00096; AP009048; X52114 

Genbank Nucleotide ID

 AAA17745.1; AAA24771.1; AAA58088.1; AAC76316.1; BAE78001.1; CAA36360.1 

Protein Name

 Large-conductance mechanosensitive channel 

Protein Synonyms/Alias

  

Gene Name

 mscL 

Gene Synonyms/Alias

 yhdC; b3291; JW3252 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
5	***MSIIKEFREFAM	acetylation	[1]
130	TEIRDLLKEQNNRS*	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Participates in the regulation of osmotic pressure changes within the cell. Forms a nonselective ion channel of 2.5 nanosiemens conductance. Opens at a pressure just below that which would cause cell disruption and death. 

Sequence Annotation

  

Keyword

 3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 136 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008381; F:mechanically-gated ion channel activity; IMP:EcoCyc.
 GO:0009992; P:cellular water homeostasis; IGI:EcoCyc. 

Interpro

 IPR019823; Mechanosensitive_channel_CS.
 IPR001185; MS_channel. 

Pfam

 PF01741; MscL 

SMART

  

PROSITE

 PS01327; MSCL 

PRINTS

 PR01264; MECHCHANNEL.