CPLM-020295

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-020295

UniProt Accession

CDK19_HUMAN; Q9BWU1; Q5JQZ7; Q5JR00; Q8TC78; Q9UPX2

Genbank Protein ID

AY028424; Z84480; AL512430; AL603914; AL512430; AL603914; AL512430; AL603914; Z84480; AL603914; AL512430; AL603914; AL512430; Z84480; BC024247; BC037289; AB028951

Genbank Nucleotide ID

AAK27731.1; CAI20520.1; CAI20520.1; CAI20520.1; CAI40282.1; CAI40282.1; CAI40286.1; CAI40286.1; CAI40286.1; CAI41172.1; CAI41172.1; CAI41175.1; CAI41175.1; CAI41175.1; AAH24247.1; AAH37289.1; BAA82980.2

Protein Name

Cyclin-dependent kinase 19

Protein Synonyms/Alias

CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase

Gene Name

CDK19

Gene Synonyms/Alias

CDC2L6; CDK11; KIAA1028

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
322	LLTMDPTKRITSEQA	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Sequence Annotation

DOMAIN 21 335 Protein kinase.
NP_BIND 27 35 ATP (By similarity).
ACT_SITE 151 151 Proton acceptor (By similarity).
BINDING 52 52 ATP (By similarity).
MOD_RES 449 449 Phosphoserine.

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

502 AA

Protein Sequence

MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA LKQIEGTGIS 60
MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120
MQLPRSMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 180
NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 240
IKTSNPFHHD QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH 300
KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ IPYPKREFLN 360
EDDPEEKGDK NQQQQQNQHQ QPTAPPQQAA APPQAPPPQQ NSTQTNGTAG GAGAGVGGTG 420
AGLQHSQDSS LNQVPPNKKP RLGPSGANSG GPVMPSDYQH SSSRLNYQSS VQGSSQSQST 480
LGYSSSSQQS SQYHPSHQAH RY 502

Gene Ontology

GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC.

Interpro

IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.

Pfam

PF00069; Pkinase

SMART

SM00220; S_TKc

PROSITE

PS00107; PROTEIN_KINASE_ATP
PS50011; PROTEIN_KINASE_DOM
PS00108; PROTEIN_KINASE_ST

PRINTS