CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030510
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium-binding mitochondrial carrier protein Aralar1 
Protein Synonyms/Alias
 cDNA FLJ33752 fis, clone BRCAN2000364, highly similar to Calcium-binding mitochondrial carrier protein Aralar1 
Gene Name
 SLC25A12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
143RKDVEVTKEEFAQSAubiquitination[1]
299VAPEKAIKLTVNDFVubiquitination[2]
375LGIFGLYKGAKACFLubiquitination[2, 3]
378FGLYKGAKACFLRDIubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 571 AA 
Protein Sequence
MENVKEIFGQ TIIHHHIPFN WDCEFIRLHF GHNRKKHLNY TEFTQFLQEL QLEHARQAFA 60
LKDKSKSGMI SGLDFSDIMV TIRSHMLTPF VEENLVSAAG GSISHQVSFS YFNAFNSLLN 120
NMELVRKIYS TLAGTRKDVE VTKEEFAQSA IRYGQVTPLE IDILYQLADL YNASGRLTLA 180
DIERIAPLAE GALPYNLAEL QRQQSPGLGR PIWLQIAESA YRFTLGSVAG AVGATAVYPI 240
DLVKTRMQNQ RGSGSVVGEL MYKNSFDCFK KVLRYEGFFG LYRGLIPQLI GVAPEKAIKL 300
TVNDFVRDKF TRRDGSVPLP AEVLAGGCAG GSQVIFTNPL EIVKIRLQVA GEITTGPRVS 360
ALNVLRDLGI FGLYKGAKAC FLRDIPFSAI YFPVYAHCKL LLADENGHVG GLNLLAAGAM 420
AGVPAASLVT PADVIKTRLQ VAARAGQTTY SGVIDCFRKI LREEGPSAFW KGTAARVFRS 480
SPQFGVTLVT YELLQRWFYI DFGGLKPAGS EPTPKSRIAD LPPANPDHIG GYRLATATFA 540
GIENKFGLYL PKFKSPSVAV VQPKAAVAAT Q 571 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50920; SOLCAR 
PRINTS
 PR00926; MITOCARRIER.