CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023827
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Malignant fibrous histiocytoma-amplified sequence 1 
Protein Synonyms/Alias
 Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1 
Gene Name
 MFHAS1 
Gene Synonyms/Alias
 MASL1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
10GMDSGNLKTARLWRDubiquitination[1]
387PPYEVCMKGIPYIAAubiquitination[1]
563RQIALQEKHDAEGLSubiquitination[1]
601AYYGVSDKNLRRRKAacetylation[2, 3, 4]
641HLRRLRDKLLSVAEHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 REPEAT 64 85 LRR 1.
 REPEAT 88 109 LRR 2.
 REPEAT 112 133 LRR 3.
 REPEAT 136 157 LRR 4.
 REPEAT 159 180 LRR 5.
 REPEAT 182 203 LRR 6.
 REPEAT 205 226 LRR 7.
 REPEAT 228 249 LRR 8.
 REPEAT 251 272 LRR 9.
 REPEAT 274 296 LRR 10.
 REPEAT 297 318 LRR 11.
 REPEAT 320 341 LRR 12.
 REPEAT 343 364 LRR 13.
 DOMAIN 403 649 Roc.
 MOD_RES 601 601 N6-acetyllysine.  
Keyword
 Acetylation; Chromosomal rearrangement; Complete proteome; Leucine-rich repeat; Polymorphism; Reference proteome; Repeat; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1052 AA 
Protein Sequence
MAGMDSGNLK TARLWRDAAL RARKLRSNLR QLTLTAAGAC PGAGADALES PASPQLVLPA 60
NLGDIEALNL GNNGLEEVPE GLGSALGSLR VLVLRRNRFA RLPPAVAELG HHLTELDVSH 120
NRLTALGAEV VSALRELRKL NLSHNQLPAL PAQLGALAHL EELDVSFNRL AHLPDSLSCL 180
SRLRTLDVDH NQLTAFPRQL LQLVALEELD VSSNRLRGLP EDISALRALK ILWLSGAELG 240
TLPAGFCELA SLESLMLDNN GLQALPAQFS CLQRLKMLNL SSNLFEEFPA ALLPLAGLEE 300
LYLSRNQLTS VPSLISGLGR LLTLWLDNNR IRYLPDSIVE LTGLEELVLQ GNQIAVLPDH 360
FGQLSRVGLW KIKDNPLIQP PYEVCMKGIP YIAAYQKELA HSQPAVQPRL KLLLMGHKAA 420
GKTLLRHCLT EERVEGCPGG GDKEKCYPPS PPPVSKGIEV TSWTADASRG LRFIVYDLAG 480
DESYEVIQPF FLSPGALYVL VVNLATYEPR HFPTTVGSFL HRVGARVPHA VVCIVGTHAD 540
LCGERELEEK CLDIHRQIAL QEKHDAEGLS RLAKVVDEAL ARDFELRSAS PHAAYYGVSD 600
KNLRRRKAHF QYLLNHRLQI LSPVLPVSCR DPRHLRRLRD KLLSVAEHRE IFPNLHRVLP 660
RSWQVLEELH FQPPQAQRLW LSWWDSARLG LQAGLTEDRL QSALSYLHES GKLLYFEDSP 720
ALKEHVFHNL TRLIDILNVF FQRDPSLLLH KLLLGTSGEG KAEGESSPPM ARSTPSQELL 780
RATQLHQYVE GFLLHGLLPA HVIRLLLKPH VQAQQDLQLL LELLEKMGLC YCLNKPKGKP 840
LNGSTAWYKF PCYVQNEVPH AEAWINGTNL AGQSFVAEQL QIEYSFPFTF PLGLFARYSV 900
QINSHVVHRS DGKFQIFAYR GKVPVVVSYR PARGVLQPDT LSIASHASLP NIWTAWQAIT 960
PLVEELNVLL QEWPGLHYTV HILCSKCLKR GSPNPHAFPG ELLSQPRPEG VAEIICPKNG 1020
SERVNVALVY PPTPTVISPC SKKNVGEKHR NQ 1052 
Gene Ontology
  
Interpro
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR027417; P-loop_NTPase.
 IPR020859; ROC_GTPase. 
Pfam
 PF00560; LRR_1 
SMART
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR
 PS51424; ROC 
PRINTS