CPLM-014646

Genbank Nucleotide ID

Histone H2B type 2-E

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
12	AKSAPAPKKGSKKAV	acetylation	[1]
13	KSAPAPKKGSKKAVT	acetylation	[1]
16	PAPKKGSKKAVTKAQ	acetylation	[1]
17	APKKGSKKAVTKAQK	acetylation	[1]
21	GSKKAVTKAQKKDGK	acetylation	[1]
24	KAVTKAQKKDGKKRK	acetylation	[1]
25	AVTKAQKKDGKKRKR	acetylation	[1]
47	IYVYKVLKQVHPDTG	acetylation	[2]
47	IYVYKVLKQVHPDTG	ubiquitination	[3]
109	LLPGELAKHAVSEGT	acetylation	[1]
121	EGTKAVTKYTSAK**	acetylation	[4]
121	EGTKAVTKYTSAK**	succinylation	[4]
121	EGTKAVTKYTSAK**	ubiquitination	[3]

[1] Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain.
Tweedie-Cullen RY, Reck JM, Mansuy IM.
J Proteome Res. 2009 Nov;8(11):4966-82. [PMID: 19737024]
[2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]

Functional Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

MOD_RES 2 2 N-acetylproline (By similarity).
MOD_RES 6 6 N6-acetyllysine; alternate (By
MOD_RES 6 6 N6-crotonyl-L-lysine; alternate.
MOD_RES 12 12 N6-acetyllysine; alternate.
MOD_RES 12 12 N6-crotonyl-L-lysine; alternate.
MOD_RES 13 13 N6-acetyllysine; alternate.
MOD_RES 13 13 N6-crotonyl-L-lysine; alternate.
MOD_RES 15 15 Phosphoserine; by STK4/MST1.
MOD_RES 16 16 N6-acetyllysine; alternate.
MOD_RES 16 16 N6-crotonyl-L-lysine; alternate.
MOD_RES 17 17 N6-acetyllysine; alternate.
MOD_RES 17 17 N6-crotonyl-L-lysine; alternate.
MOD_RES 21 21 N6-acetyllysine; alternate.
MOD_RES 21 21 N6-crotonyl-L-lysine; alternate.
MOD_RES 24 24 N6-acetyllysine; alternate (By
MOD_RES 24 24 N6-crotonyl-L-lysine; alternate.
MOD_RES 35 35 N6-crotonyl-L-lysine; alternate.
MOD_RES 37 37 Phosphoserine; by AMPK.
MOD_RES 43 43 Phosphotyrosine (By similarity).
MOD_RES 47 47 N6-methyllysine (By similarity).
MOD_RES 58 58 N6,N6-dimethyllysine (By similarity).
MOD_RES 109 109 N6-methyllysine (By similarity).
MOD_RES 113 113 Phosphoserine (By similarity).
CROSSLNK 35 35 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 121 121 Glycyl lysine isopeptide (Lys-Gly)

Acetylation; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0006334; P:nucleosome assembly; IEA:InterPro.

IPR009072; Histone-fold.
IPR007125; Histone_core_D.
IPR000558; Histone_H2B.

PS00357; HISTONE_H2B

PR00621; HISTONEH2B.