UniProt Accession

 GNA1_HUMAN; Q96EK6 

Genbank Protein ID

 AK090577; BC012179 

Genbank Nucleotide ID

 BAC03482.1; AAH12179.1 

Protein Name

 Glucosamine 6-phosphate N-acetyltransferase 

Protein Synonyms/Alias

 Phosphoglucosamine acetylase; Phosphoglucosamine transacetylase 

Gene Name

 GNPNAT1 

Gene Synonyms/Alias

 GNA1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
2	******MKPDETPMF	ubiquitination	[1]
55	DLNRGFFKVLGQLTE	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

  

Sequence Annotation

 DOMAIN 39 184 N-acetyltransferase.
 REGION 108 111 Substrate binding.
 REGION 120 122 Substrate binding.
 REGION 130 135 Acetyl-CoA binding.
 REGION 151 152 Substrate binding.
 REGION 165 167 Acetyl-CoA binding.
 BINDING 61 61 Substrate.
 BINDING 175 175 Substrate.
 BINDING 181 181 Substrate.  

Keyword

 3D-structure; Acyltransferase; Complete proteome; Endosome; Golgi apparatus; Membrane; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:Compara.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005770; C:late endosome; IEA:Compara.
 GO:0004343; F:glucosamine 6-phosphate N-acetyltransferase activity; TAS:Reactome.
 GO:0048029; F:monosaccharide binding; IEA:Compara.
 GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; TAS:Reactome.
 GO:0006041; P:glucosamine metabolic process; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0006044; P:N-acetylglucosamine metabolic process; IEA:Compara.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome.
 GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; TAS:Reactome. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 

Pfam

 PF00583; Acetyltransf_1 

SMART

  

PROSITE

 PS51186; GNAT 

PRINTS