Tag | Content |
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CPLM ID | CPLM-024736 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3-hydroxybutyrate dehydrogenase type 2 |
Protein Synonyms/Alias | Dehydrogenase/reductase SDR family member 6; R-beta-hydroxybutyrate dehydrogenase |
Gene Name | Bdh2 |
Gene Synonyms/Alias | Dhrs6 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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42 | ATDINEAKLQELENY | acetylation | [1] | 61 | TRVLDVTKKRQIDQF | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). |
Sequence Annotation | NP_BIND 10 37 NAD (By similarity). NP_BIND 180 184 NAD (By similarity). ACT_SITE 147 147 Proton acceptor (By similarity). BINDING 58 58 NAD (By similarity). BINDING 144 144 Substrate (By similarity). BINDING 151 151 NAD (By similarity). BINDING 188 188 Substrate (By similarity). BINDING 205 205 Substrate (By similarity). |
Keyword | Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 245 AA |
Protein Sequence | MGRLEGKVIV LTAAAQGIGR ASALAFAREG AKVIATDINE AKLQELENYP GIQTRVLDVT 60 KKRQIDQFAS EIEKIDVLFN VAGFVHHGTI LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM 120 LAQKSGNIIN MSSVASSIKG VENRCVYSAT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV 180 DTPSLQERIQ ARDDPKEALK AFLNRQKTGR FASAEEVALL CVYLASDESA YVTGTPVVID 240 GGWSL 245 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003858; F:3-hydroxybutyrate dehydrogenase activity; IEA:EC. GO:0051287; F:NAD binding; IEA:Compara. GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; ISS:UniProtKB. GO:0006635; P:fatty acid beta-oxidation; IEA:Compara. GO:0042168; P:heme metabolic process; ISS:UniProtKB. GO:0055072; P:iron ion homeostasis; ISS:UniProtKB. GO:0019290; P:siderophore biosynthetic process; ISS:UniProtKB. |
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