UniProt Accession

 DCTD_HUMAN; P32321; B2R836; D3DP49; D3DP50; Q5M7Z8; Q9BVD8 

Genbank Protein ID

 L12136; L39874; AK313221; AC079766; CH471056; CH471056; CH471056; CH471056; BC001286; BC088357 

Genbank Nucleotide ID

 AAA35755.1; AAC37579.1; BAG36033.1; EAX04697.1; EAX04698.1; EAX04700.1; EAX04701.1; AAH01286.1; AAH88357.2 

Protein Name

 Deoxycytidylate deaminase 

Protein Synonyms/Alias

 dCMP deaminase 

Gene Name

 DCTD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
42	FLSAQRSKDPNSQVG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Supplies the nucleotide substrate for thymidylate synthetase. 

Sequence Annotation

 ACT_SITE 86 86 Proton donor (By similarity).
 METAL 84 84 Zinc; catalytic (By similarity).
 METAL 110 110 Zinc; catalytic (By similarity).
 METAL 113 113 Zinc; catalytic (By similarity).  

Keyword

 3D-structure; Allosteric enzyme; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Metal-binding; Nucleotide biosynthesis; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004132; F:dCMP deaminase activity; EXP:Reactome.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
 GO:0006206; P:pyrimidine nucleobase metabolic process; TAS:Reactome.
 GO:0046134; P:pyrimidine nucleoside biosynthetic process; TAS:Reactome.
 GO:0006220; P:pyrimidine nucleotide metabolic process; TAS:ProtInc. 

Interpro

 IPR016192; APOBEC/CMP_deaminase_Zn-bd.
 IPR002125; CMP_dCMP_Zn-bd.
 IPR015517; Cyt_deaminase.
 IPR016193; Cytidine_deaminase-like.
 IPR016473; dCMP_deaminase. 

Pfam

 PF00383; dCMP_cyt_deam_1 

SMART

  

PROSITE

 PS00903; CYT_DCMP_DEAMINASES 

PRINTS