UniProt Accession

 S14L2_HUMAN; O76054; B7Z8Q1; F5H3U4; Q53EQ2; Q6PD61; Q9ULN4 

Genbank Protein ID

 AL096881; AB033012; CR456571; AK303751; AK223587; AC004832; BC058915 

Genbank Nucleotide ID

 CAB51405.1; BAA86500.2; CAG30457.1; BAH14037.1; BAD97307.1; AAF19256.1; AAH58915.1 

Protein Name

 SEC14-like protein 2 

Protein Synonyms/Alias

 Alpha-tocopherol-associated protein; TAP; hTAP; Squalene transfer protein; Supernatant protein factor; SPF 

Gene Name

 SEC14L2 

Gene Synonyms/Alias

 C22orf6; KIAA1186; KIAA1658 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
196	LFVVKAPKLFPVAYN	ubiquitination	[1, 2]
225	MVLGANWKEVLLKHI	ubiquitination	[3]
255	PDGNPKCKSKINYGG	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. 

Sequence Annotation

 DOMAIN 76 249 CRAL-TRIO.
 DOMAIN 275 383 GOLD.  

Keyword

 3D-structure; Activator; Alternative splicing; Complete proteome; Cytoplasm; Lipid-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 403 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0005543; F:phospholipid binding; NAS:UniProtKB.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0008431; F:vitamin E binding; NAS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0045540; P:regulation of cholesterol biosynthetic process; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001071; CRAL-bd_toc_tran.
 IPR001251; CRAL-TRIO_dom.
 IPR011074; CRAL/TRIO_N_dom.
 IPR009038; GOLD. 

Pfam

 PF00650; CRAL_TRIO
 PF03765; CRAL_TRIO_N 

SMART

 SM01100; CRAL_TRIO_N
 SM00516; SEC14 

PROSITE

 PS50191; CRAL_TRIO
 PS50866; GOLD 

PRINTS

 PR00180; CRETINALDHBP.