CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002230
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 2E1 
Protein Synonyms/Alias
 4-nitrophenol 2-hydroxylase; CYPIIE1; Cytochrome P450-J; Cytochrome P450RLM6 
Gene Name
 Cyp2e1 
Gene Synonyms/Alias
 Cyp2e; Cyp2e-1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
59DIPKSFTKLAKRFGPacetylation[1]
87LHGYKAVKEVLLNHKacetylation[1]
243MKNVSEIKQYTLEKAacetylation[1]
410FPDPEKFKPEHFLNEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites (By similarity). 
Sequence Annotation
 REGION 298 303 Substrate binding (By similarity).
 METAL 437 437 Iron (heme axial ligand).
 MOD_RES 129 129 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MAVLGITIAL LVWVATLLVI SIWKQIYNSW NLPPGPFPLP ILGNIFQLDL KDIPKSFTKL 60
AKRFGPVFTL HLGSRRIVVL HGYKAVKEVL LNHKNEFSGR GDIPVFQEYK NKGIIFNNGP 120
TWKDVRRFSL SILRDWGMGK QGNEARIQRE AQFLVEELKK TKGQPFDPTF LIGCAPCNVI 180
ADILFNKRFD YNDKKCLRLM SLFNENFYLL STPWIQLYNN FADYLRYLPG SHRKIMKNVS 240
EIKQYTLEKA KEHLQSLDIN CARDVTDCLL IEMEKEKHSQ EPMYTMENVS VTLADLFFAG 300
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRVPA VRDRLDMPYM DAVVHEIQRF 360
INLVPSNLPH EATRDTVFQG YVIPKGTVVI PTLDSLLYDS HEFPDPEKFK PEHFLNENGK 420
FKYSDYFKAF SAGKRVCVGE GLARMELFLL LSAILQHFNL KSLVDPKDID LSPVTVGFGS 480
IPPQFKLCVI PRS 493 
Gene Ontology
 GO:0000139; C:Golgi membrane; IDA:RGD.
 GO:0031227; C:intrinsic to endoplasmic reticulum membrane; IDA:RGD.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0010181; F:FMN binding; IC:RGD.
 GO:0020037; F:heme binding; ISS:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IEA:EC.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IDA:RGD.
 GO:0017144; P:drug metabolic process; IEA:Compara.
 GO:0046483; P:heterocycle metabolic process; IEA:Compara.
 GO:0016098; P:monoterpenoid metabolic process; IEA:Compara.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0010243; P:response to organic nitrogen; IEP:RGD.
 GO:0010193; P:response to ozone; IEP:RGD.
 GO:0008202; P:steroid metabolic process; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IMP:RGD.
 GO:0006805; P:xenobiotic metabolic process; IMP:RGD. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008070; Cyt_P450_E_grp-I_CYP2E-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01687; EP450ICYP2E.
 PR00385; P450.