UniProt Accession

 TOM22_HUMAN; Q9NS69 

Genbank Protein ID

 AB040119; AB041906; AK024731; CR456475; BC009363 

Genbank Nucleotide ID

 BAB03306.1; BAB16408.1; BAB14979.1; CAG30361.1; AAH09363.1 

Protein Name

 Mitochondrial import receptor subunit TOM22 homolog 

Protein Synonyms/Alias

 hTom22; 1C9-2; Translocase of outer membrane 22 kDa subunit homolog 

Gene Name

 TOMM22 

Gene Synonyms/Alias

 TOM22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	LPKGDAEKPEEELEE	ubiquitination	[1]
141	ALPSLPGKI******	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. 

Sequence Annotation

 REGION 41 50 Import sequence; necessary for
 REGION 83 103 TMD; necessary for mitochondrion outer
 REGION 123 142 C-tail signal; necessary for
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 43 43 Phosphothreonine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Protein transport; Receptor; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IDA:BHF-UCL.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005742; C:mitochondrial outer membrane translocase complex; IDA:BHF-UCL.
 GO:0008320; F:protein transmembrane transporter activity; ISS:BHF-UCL.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0045040; P:protein import into mitochondrial outer membrane; IDA:BHF-UCL. 

Interpro

 IPR005683; Tom22. 

Pfam

 PF04281; Tom22 

SMART

  

PROSITE

  

PRINTS