CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002578
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA excision repair protein ERCC-1 
Protein Synonyms/Alias
  
Gene Name
 ERCC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37EVPPGVAKPLFRSTQubiquitination[1]
114QRGNPVLKFVRNVPWubiquitination[1]
162GRLQSLGKNFALRVLubiquitination[1, 2, 3]
176LLVQVDVKDPQQALKubiquitination[1]
213GRYLETYKAYEQKPAubiquitination[1]
226PADLLMEKLEQDFVSubiquitination[1]
243TECLTTVKSVNKTDSubiquitination[1]
281CPGLGPQKARRLFDVubiquitination[1]
295VLHEPFLKVP*****ubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. 
Sequence Annotation
 DNA_BIND 134 156 Potential.
 MOTIF 17 23 Nuclear localization signal (Potential).  
Keyword
 3D-structure; Alternative splicing; Cataract; Complete proteome; DNA damage; DNA repair; DNA-binding; Endonuclease; Hydrolase; Nuclease; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 297 AA 
Protein Sequence
MDPGKDKEGV PQPSGPPARK KFVIPLDEDE VPPGVAKPLF RSTQSLPTVD TSAQAAPQTY 60
AEYAISQPLE GAGATCPTGS EPLAGETPNQ ALKPGAKSNS IIVSPRQRGN PVLKFVRNVP 120
WEFGDVIPDY VLGQSTCALF LSLRYHNLHP DYIHGRLQSL GKNFALRVLL VQVDVKDPQQ 180
ALKELAKMCI LADCTLILAW SPEEAGRYLE TYKAYEQKPA DLLMEKLEQD FVSRVTECLT 240
TVKSVNKTDS QTLLTTFGSL EQLIAASRED LALCPGLGPQ KARRLFDVLH EPFLKVP 297 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0000784; C:nuclear chromosome, telomeric region; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000109; C:nucleotide-excision repair complex; IDA:UniProtKB.
 GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0051276; P:chromosome organization; IEA:Compara.
 GO:0006302; P:double-strand break repair; IEA:Compara.
 GO:0048568; P:embryonic organ development; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0045190; P:isotype switching; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0006312; P:mitotic recombination; IMP:UniProtKB.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0010259; P:multicellular organismal aging; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0032205; P:negative regulation of telomere maintenance; IMP:UniProtKB.
 GO:0000718; P:nucleotide-excision repair, DNA damage removal; TAS:Reactome.
 GO:0006295; P:nucleotide-excision repair, DNA incision, 3'-to lesion; IMP:UniProtKB.
 GO:0006296; P:nucleotide-excision repair, DNA incision, 5'-to lesion; IMP:UniProtKB.
 GO:0048477; P:oogenesis; IEA:Compara.
 GO:0035166; P:post-embryonic hemopoiesis; IEA:Compara.
 GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IEA:Compara.
 GO:0001302; P:replicative cell aging; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IMP:UniProtKB.
 GO:0009744; P:response to sucrose stimulus; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0006949; P:syncytium formation; IEA:Compara.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome.
 GO:0009650; P:UV protection; IEA:Compara. 
Interpro
 IPR004579; DNA_repair_Rad10.
 IPR000445; HhH_motif.
 IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
 IPR011335; Restrct_endonuc-II-like.
 IPR010994; RuvA_2-like. 
Pfam
 PF00633; HHH
 PF03834; Rad10 
SMART
 SM00278; HhH1 
PROSITE
  
PRINTS