UniProt Accession

 UB2L6_MOUSE; Q9QZU9; Q3U8R0; Q922F1; Q9CQN0 

Genbank Protein ID

 AF159230; AK010942; AK013452; AK152010; AK152113; AK168695; AK171629; CH466519; BC008238 

Genbank Nucleotide ID

 AAD55978.1; BAB27282.1; BAB28861.1; BAE30873.1; BAE30957.1; BAE40539.1; BAE42574.1; EDL27303.1; AAH08238.1 

Protein Name

 Ubiquitin/ISG15-conjugating enzyme E2 L6 

Protein Synonyms/Alias

 UbcM8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6 

Gene Name

 Ube2l6 

Gene Synonyms/Alias

 Ubce8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
9	MASKRVAKELESLSK	ubiquitination	[1]
16	KELESLSKELPPYLR	ubiquitination	[1]
64	FPREYPFKPPTLRFT	ubiquitination	[1]
73	PTLRFTTKIYHPNVR	ubiquitination	[1]
139	NPEMFRKKAEEFTLK	ubiquitination	[1]
146	KAEEFTLKFGVDRPS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 (By similarity). 

Sequence Annotation

 ACT_SITE 86 86 Glycyl thioester intermediate (By  

Keyword

 ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042296; F:ISG15 ligase activity; IDA:MGI.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
 GO:0032020; P:ISG15-protein conjugation; IDA:MGI.
 GO:0019941; P:modification-dependent protein catabolic process; IDA:MGI. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR023313; UBQ-conjugating_AS.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS