CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008512
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoporin NUP188 
Protein Synonyms/Alias
 Nuclear pore protein NUP188 
Gene Name
 NUP188 
Gene Synonyms/Alias
 YML103C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
232RNINSTDKSIDTSSLubiquitination[1]
406VFAKIISKAPEQFIEubiquitination[1, 2]
1653ALQDSLFKDV*****ubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP188 probably plays an important role in NPC assembly and organization. 
Sequence Annotation
 REGION 250 271 Leucine-zipper.
 MOD_RES 340 340 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Direct protein sequencing; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1655 AA 
Protein Sequence
MATPSFGNSS PQLTFTHVAN FMNDAAADVS AVDAKQLAQI RQFLKANKTN LIESLNTIRQ 60
NVTSSGDHNK LRSTIANLLQ INVDNDPFFA QSEDLSHAVE FFMSERSSRL HIVYSLLVNP 120
DIDLETYSFI DNDRFNVVGK LISIISSVIQ NYDIITASSL AHDYNNDQDM FTIVSLVQLK 180
KFSDLKFILQ ILQILNLMIL NTKVPVDIVN QWFLQYQNQF VEFCRNINST DKSIDTSSLQ 240
LYKFQNFQDL SYLSETLISR ISSLFTITTI LILGLNTSIA QFDIQSPLYM DTETFDTVNS 300
ALENDVATNI VNEDPIFHPM IHYSWSFILY YRRALQSSES FDDSDITKFA LFAESHDVLQ 360
KLNTLSEILS FDPVYTTVIT VFLEFSLNFI PITASTSRVF AKIISKAPEQ FIENFLTNDT 420
FEKKLSIIKA KLPLLNESLI PLINLALIDT EFANFELKDI CSFAVTKSSL NDLDYDLIAD 480
TITNSSSSSD IIVPDLIELK SDLLVAPPLE NENSNCLLSI PKSTKGKILT IKQQQQQQQQ 540
QNGQQPPTTS NLIIFLYKFN GWSLVGRILQ NLLHSYMEKG TQLDDLQHEL MISIIKLVTN 600
VVDPKTSIEK SSEILSYLSN SLDTSASTIN GASIIQVIFE IFEISLQRKD YTSIVQCCEF 660
MTMLTPNYLH LVSSYLNKSD LLDKYGKTGL SNMILGSVEL STGDYTFTIQ LLKLTKVFIR 720
ESLSLKNIHI SKRSKIDIIN KLILHAIHIF ESYYNWKYNN FLQKFEIAFH LTLIFYDVLH 780
DVFTINPHQK DQLIISSSAN KLLQLFLTPM DSIDLAPNTL TNILISPLNT TTKILGDKIL 840
GNLYSKVMNN SFKLCTLLIA IRGSNRDLKP SNLEKLLFIN SSKLVDVYTL PSYVHFKVQI 900
IELLSYLVEA PWNDDYPFLL SFLGEAKSMA FLKEVLSDLS SPVQDWNLLR SLYIFFTTLL 960
ESKQDGLSIL FLTGQFASNK KINDESSIDK KSSILTVLQK NSLLLDSTPE EVSCKLLETI 1020
TYVLNTWTNS KIFIKDPKFV NSLLAKLKDS KKLFQKKENL TRDETVSLIK KYKLISRIVE 1080
IFALCIYNST DSNSEILNFL NQEDLFELVH HFFQIDGFNK TFHDELNLKF KEKWPSLELQ 1140
SFQKIPLSRI NENENFGYDI PLLDIVLKAD RSWNEPSKSQ TNFKEEITDA SLNLQYVNYE 1200
ISTAKAWGAL ITTFVKRSTV PLNDGFVDLV EHFLKLNIDF GSDKQMFTQI YLERIELSFY 1260
ILYSFKLSGK LLKEEKIIEL MNKIFTIFKS GEIDFIKNIG KSLKNNFYRP LLRSVLVLLE 1320
LVSSGDRFIE LISDQLLEFF ELVFSKGVYL ILSEILCQIN KCSTRGLSTD HTTQIVNLED 1380
NTQDLLLLLS LFKKITNVNP SKNFNVILAS SLNEVGTLKV ILNLYSSAHL IRINDEPILG 1440
QITLTFISEL CSIEPIAAKL INSGLYSVLL ESPLSVAIQQ GDIKPEFSPR LHNIWSNGLL 1500
SIVLLLLSQF GIKVLPETCL FVSYFGKQIK STIYNWGDNK LAVSSSLIKE TNQLVLLQKM 1560
LNLLNYQELF IQPKNSDDQQ EAVELVIGLD SEHDKKRLSA ALSKFLTHPK YLNSRIIPTT 1620
LEEQQQLEDE SSRLEFVKGI SRDIKALQDS LFKDV 1655 
Gene Ontology
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0044611; C:nuclear pore inner ring; IDA:SGD.
 GO:0017056; F:structural constituent of nuclear pore; IGI:SGD.
 GO:0031990; P:mRNA export from nucleus in response to heat stress; IMP:SGD.
 GO:0006999; P:nuclear pore organization; IMP:SGD.
 GO:0006606; P:protein import into nucleus; IGI:SGD. 
Interpro
 IPR018864; Nucleoporin_Nup188. 
Pfam
 PF10487; Nup188 
SMART
  
PROSITE
  
PRINTS