CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020530
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U2 small nuclear ribonucleoprotein B'' 
Protein Synonyms/Alias
 U2 snRNP B'' 
Gene Name
 Snrpb2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
85PMRIQYAKTDSDIISubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A' protein (By similarity). 
Sequence Annotation
 DOMAIN 7 86 RRM 1.
 DOMAIN 151 225 RRM 2.
 MOD_RES 151 151 Phosphotyrosine (By similarity).  
Keyword
 Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 225 AA 
Protein Sequence
MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG QAFVIFKELG 60
SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD KEKKKEKKKA KTMEQAAAAA 120
NKKPGQGTPN AANTQGTAAP NPQVPDYPPN YILFLNNLPE ETNEMMLSML FNQFPGFKEV 180
RLVPGRHDIA FVEFENDGQA GAARDALQGF KITPSHAMKI TYAKK 225 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0017069; F:snRNA binding; IEA:InterPro.
 GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR024888; U1_snRNP_A/U2_snRNP_B''. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS