UniProt Accession

 RM18_HUMAN; Q9H0U6; Q5TAP9; Q9NZW8 

Genbank Protein ID

 AL136633; AF161556; CR533491; AL139045; AL135914; AL135914; AL139045; BC001623 

Genbank Nucleotide ID

 CAB66568.1; AAF29043.1; CAG38522.1; CAI19751.1; CAI19751.1; CAI21852.1; CAI21852.1; AAH01623.1 

Protein Name

 39S ribosomal protein L18, mitochondrial 

Protein Synonyms/Alias

 L18mt; MRP-L18 

Gene Name

 MRPL18 

Gene Synonyms/Alias

 HSPC071 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	TSSEPAAKPEVDPVE	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA. 

Sequence Annotation

  

Keyword

 Chaperone; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 180 AA 

Protein Sequence

Gene Ontology

 GO:0005761; C:mitochondrial ribosome; NAS:UniProtKB.
 GO:0008097; F:5S rRNA binding; IDA:UniProtKB.
 GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
 GO:0035928; P:rRNA import into mitochondrion; IDA:UniProtKB.
 GO:0006412; P:translation; NAS:UniProtKB. 

Interpro

 IPR005484; Ribosomal_L18/L5. 

Pfam

 PF00861; Ribosomal_L18p 

SMART

  

PROSITE

  

PRINTS