UniProt Accession

 E9Q133_MOUSE; E9Q133 

Genbank Protein ID

 AC044864 

Genbank Nucleotide ID

  

Protein Name

 T-complex protein 1 subunit gamma 

Protein Synonyms/Alias

  

Gene Name

 Cct3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
100	DDMISTLKKISTPVD	acetylation	[1, 2]
100	DDMISTLKKISTPVD	succinylation	[2]
100	DDMISTLKKISTPVD	ubiquitination	[3]
101	DMISTLKKISTPVDV	ubiquitination	[3]
165	KKYARVEKIPGGIIE	acetylation	[1]
184	LRGVMINKDVTHPRM	acetylation	[1, 4]
210	LDSSLEYKKGESQTD	acetylation	[4]
210	LDSSLEYKKGESQTD	ubiquitination	[3]
343	ILLRGASKEILSEVE	acetylation	[2, 4]
343	ILLRGASKEILSEVE	succinylation	[2]
343	ILLRGASKEILSEVE	ubiquitination	[3]
387	VAHALTEKSKAMTGV	ubiquitination	[3]
469	AVKLQTYKTAVETAV	acetylation	[1]
469	AVKLQTYKTAVETAV	ubiquitination	[3]
489	DDIVSGHKKKGDDQN	ubiquitination	[3]
490	DIVSGHKKKGDDQNR	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 507 AA 

Protein Sequence

Gene Ontology

 GO:0044297; C:cell body; IDA:MGI.
 GO:0005832; C:chaperonin-containing T-complex; IDA:MGI.
 GO:0002199; C:zona pellucida receptor complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0007339; P:binding of sperm to zona pellucida; IDA:MGI.
 GO:0006457; P:protein folding; IEA:InterPro. 

Interpro

 IPR012719; Chap_CCT_gamma.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 

Pfam

 PF00118; Cpn60_TCP1 

SMART

  

PROSITE

 PS00995; TCP1_3 

PRINTS

 PR00304; TCOMPLEXTCP1.