CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018958
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pre-rRNA-processing protein TSR2 homolog 
Protein Synonyms/Alias
  
Gene Name
 TSR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
44VHSQEKAKWLGGAVEubiquitination[1, 2]
121CITQRKCKVTATALKubiquitination[3]
128KVTATALKTARETDEubiquitination[4, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 May be involved in 20S pre-rRNA processing (Potential). 
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 191 AA 
Protein Sequence
MAGAAEDARA LFRAGVCAAL EAWPALQIAV ENGFGGVHSQ EKAKWLGGAV EDYFMRNADL 60
ELDEVEDFLG ELLTNEFDTV VEDGSLPQVS QQLQTMFHHF QRGDGAALRE MASCITQRKC 120
KVTATALKTA RETDEDEDDV DSVEEMEVTA TNDGAATDGV CPQPEPSDPD AQTIKEEDIV 180
EDGWTIVRRK K 191 
Gene Ontology
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR019398; Pre-rRNA_process_TSR2. 
Pfam
 PF10273; WGG 
SMART
  
PROSITE
  
PRINTS