CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030865
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ60565, highly similar to Nuclear pore complex protein Nup153 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15VGGGGGGKIRTRRCHubiquitination[1]
27RCHQGPIKPYQQGRQubiquitination[2]
48SRVTESVKNIVPGWLubiquitination[1, 2, 3]
263DSPFYPGKTTYGGAAubiquitination[2, 3]
384TNRSVYFKPSLTPSGubiquitination[3]
985SEGFKFSKPIGDFKFubiquitination[3]
991SKPIGDFKFGVSSESubiquitination[3]
1151STSLVFGKKADNEEPubiquitination[3]
1179TKDENSSKSTFSFSMubiquitination[3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1506 AA 
Protein Sequence
MASGAGGVGG GGGGKIRTRR CHQGPIKPYQ QGRQQHQGIL SRVTESVKNI VPGWLQRYFN 60
KNEDVCSCST DTSEVPRWPE NKEDHLVYAD EESSNITDGR ITPEPAVSNT GEPSTTSTAS 120
NYPDVLTRPS LHRSHLNFSM LESPALHCQP STSSAFPIGS SGFSLVKEIK DSTSQHDDDN 180
ISTTSGFSSR ASDKDITVSK NTSLPPLWSP EAERSHSLSQ HTATSSKKPA FNLSAFGTLS 240
PSLGNSSILK TSQLGDSPFY PGKTTYGGAA AAVRQSKLRN TPYQAPVRRQ MKAKQLSAQS 300
YGVTSSTARR ILQSLEKMSS PLADAKRIPS IVSSPLNSPL DRSGIDITDF QAKREKVDSQ 360
YPPVQRLMTP KPVSIATNRS VYFKPSLTPS GEFRKTNQRI DNKCSTGYEK NMTPGQNREQ 420
RESGFSYPNF SLPAANGLSS GVGGGGGKMR RERTRFVASK PLEEERQGLT VLPKLISSSC 480
AQAIIPSWPL KVLRLQEMEV PVLPKISLPI TSSSLPTFNF SSPEITTSSP SPINSSQALT 540
NKVQMTSPSS TGSPMFKFSS PIVKSTEANV LPPSSIGFTF SVPVAKTAEL SGSSSTLEPI 600
ISSSAHHVTT VNSTNCKKTP PEDCEGPFRP AEILKEGSVL DILKSPGFAS PKIDSVAAQP 660
TATSPVVYTR PAISSFSSSG IGFGESLKAG SSWQCDTCLL QNKVTDNKCI ACQAAKLSPR 720
DTAKQTGIET PNKSGKTTLS ASGTGFGDKF KPVIGTWDCD TCLVQNKPEA IKCVACETPK 780
PGTCVKRALT LTVVSESAET MTASSSSCTV TTGTLGFGDK FKRPIGSWEC SVCCVSNNAE 840
DNKSVSCMSE KPGSSVPTSS SSTVPVCLPS GGSLGLEKFK KPEGSWDCEL CLVQNKADST 900
KCLACESAKP GTKSGFKGFD TSSSSSNSAA SSSFKFGVSS SSSGPSQTLT STGNFKFGDQ 960
GGFKIGVSSD SGSINPMSEG FKFSKPIGDF KFGVSSESKP EEVKKDSKND NFKFGLSSGL 1020
SNPVSLTPFQ FGVSNLGQEE KKEELPKSSS AGFSFGTGVI NSTPAPANTI VTSENKSSFN 1080
LGTIETKSAS VAPFTCKTSE AKKEEMPATK GGFSFGNVEP ASLPSASVFV LGRTEEKQQE 1140
PVTSTSLVFG KKADNEEPKC QPVFSFGNSE QTKDENSSKS TFSFSMTKPS EKESEQPAKA 1200
TFAFGAQTST TADQGAAKPV FSFLNNSSSS SSTPATSAGG GIFGSSTSSS NPPVATFVFG 1260
QSSNPVSSSA FGNTAESSTS QSLLFSQDSK LATTSSTGTA VTPFVFGPGA SSNNTTTSGF 1320
GFGATTTSSS AGSSFVFGTG PSAPSASPAF GANQTPTFGQ SQGASQPNPP GFGSISSSTA 1380
LFPTGSQPAP PTFGTVSSSS QPPVFGQQPS QSAFGSGTTP NSSSAFQFGS STTNFNFTNN 1440
SPSGVFTFGA NSSTPAASAQ PSGSGGFPFN QSPAAFTVGS NGKNVFSSSG TSFSGRKIKT 1500
AVRRRK 1506 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR026054; Nucleoporin.
 IPR013913; Nucleoporin_Nup153.
 IPR018892; Retro-transposon_transp_CS.
 IPR001876; Znf_RanBP2. 
Pfam
 PF08604; Nup153
 PF10599; Nup_retrotrp_bd
 PF00641; zf-RanBP 
SMART
 SM00547; ZnF_RBZ 
PROSITE
 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 
PRINTS