| Tag | Content |
|---|
| CPLM ID | CPLM-007435 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone acetyltransferase SAS2 |
Protein Synonyms/Alias | Something about silencing protein 2 |
Gene Name | SAS2 |
Gene Synonyms/Alias | ESO1; YMR127C; YM9553.03C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 15 | SLTATTQKLKGKKNG | acetylation | [1] | | 17 | TATTQKLKGKKNGGK | acetylation | [1] | | 38 | AKIKKTQKEMLYGIL | acetylation | [1] | | 168 | TKLYLDNKSMYFKVD | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Histone acetyltransferase (HAT) subunit of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing and G0 control. |
Sequence Annotation | ZN_FING 101 123 C2HC-type.
REGION 216 222 Acetyl-CoA binding (By similarity).
ACT_SITE 168 168 By similarity.
ACT_SITE 208 208 Nucleophile (By similarity).
BINDING 246 246 Acetyl-CoA (By similarity).
MOD_RES 168 168 N6-acetyllysine; by autocatalysis (By |
Keyword | Acetylation; Acyltransferase; Chromatin regulator; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 338 AA |
Protein Sequence | MARSLSQSLT ATTQKLKGKK NGGKGKNKPS AKIKKTQKEM LYGILNERNI RQIQFGLNKK 60
FSTWYGSAVY FDPETKRLGC SETKGQLSSV SNSQYWLDTL FVCEYCFKYT DDQTRFVGHV 120
ASCPFQYRVP GKIKYKSPEY TIRRVKGSKY QLFCQCLCLF TKLYLDNKSM YFKVDHYEFY 180
IVYETGSTKP MGFFSKDLVS YQQNNLACIL IFPPYQRRGL GLLLIEFSYK LSQLEGVISG 240
PEVPLSPFGL IGYLKYWSQI LCWHLIEGDL AHYDKVTLED LSIVTGMRVN DVILTLKHLN 300
CIGENNQIYL QSLNSWLKLH GTKRNWFKLK DEYLLIDD 338 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0000790; C:nuclear chromatin; IDA:SGD. GO:0000784; C:nuclear chromosome, telomeric region; IC:SGD. GO:0033255; C:SAS acetyltransferase complex; IDA:SGD. GO:0004402; F:histone acetyltransferase activity; IDA:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006348; P:chromatin silencing at telomere; IDA:SGD. GO:0043486; P:histone exchange; IMP:SGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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