UniProt Accession

 HTSF1_MOUSE; Q8BGC0; B1AVC7; Q1WWK0; Q9CT41; Q9DAU3 

Genbank Protein ID

 AK005527; AK011234; AK049495; AL672263; BC037711; BC114588; BC114589 

Genbank Nucleotide ID

 BAB24100.1; BAB27483.1; BAC33777.1; CAM25501.1; AAH37711.1; AAI14589.1; AAI14590.1 

Protein Name

 HIV Tat-specific factor 1 homolog 

Protein Synonyms/Alias

  

Gene Name

 Htatsf1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
200	ESVELALKLLDEDEI	ubiquitination	[1]
222	EVAKFQLKGEYDASK	ubiquitination	[1]
246	KKLSLQQKQLDWRPE	acetylation	[2]
246	KKLSLQQKQLDWRPE	ubiquitination	[1]
298	DLRVECSKFGQIRKL	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation (By similarity). 

Sequence Annotation

 DOMAIN 134 219 RRM 1.
 DOMAIN 265 350 RRM 2.
 REGION 382 757 Mediates interaction with the P-TEFb
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 388 388 Phosphoserine (By similarity).
 MOD_RES 404 404 Phosphoserine (By similarity).
 MOD_RES 408 408 Phosphoserine (By similarity).
 MOD_RES 446 446 Phosphoserine (By similarity).
 MOD_RES 528 528 Phosphoserine.
 MOD_RES 556 556 Phosphoserine (By similarity).
 MOD_RES 560 560 Phosphoserine (By similarity).
 MOD_RES 578 578 Phosphoserine.
 MOD_RES 598 598 Phosphoserine (By similarity).
 MOD_RES 604 604 Phosphoserine (By similarity).
 MOD_RES 613 613 Phosphoserine.
 MOD_RES 621 621 Phosphoserine.
 MOD_RES 645 645 Phosphoserine.
 MOD_RES 679 679 Phosphoserine.
 MOD_RES 705 705 Phosphoserine (By similarity).
 MOD_RES 724 724 Phosphoserine.  

Keyword

 Acetylation; Activator; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 757 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS