| Tag | Content |
|---|
| CPLM ID | CPLM-016673 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Anaphase-promoting complex subunit 2 |
Protein Synonyms/Alias | APC2; Cyclosome subunit 2 |
Gene Name | Anapc2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 205 | VYMQSKRKGEGGTDP | ubiquitination | [1] | | 561 | IRNVELLKLRFGEAP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. |
Sequence Annotation | MOD_RES 233 233 Phosphoserine (By similarity).
MOD_RES 329 329 Phosphoserine (By similarity).
MOD_RES 485 485 Phosphoserine (By similarity).
MOD_RES 549 549 Phosphoserine (By similarity).
MOD_RES 825 825 Phosphotyrosine. |
Keyword | Cell cycle; Cell division; Complete proteome; Differentiation; Mitosis; Neurogenesis; Phosphoprotein; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 837 AA |
Protein Sequence | MEAEGVAVAA AAAAAAAAAT IIASDDCDSR PGQELLVAWN TVSTGLVPPA ALGLASSRTS 60
GAVPPKEEEL RAAVEVLRGH GLHSVLEEWF VEVLQNDLQG NIATEFWNAI ALRENSVDEP 120
QCLGLLLDAF GLLESRLDPY LHSLELLEKW TRLGLLMGAG AQGLREKVHT MLRGVLFFST 180
PRTFQEMVQR LYGRFLRVYM QSKRKGEGGT DPELEGELDS RYARRRYYRL LQSPLCAGCG 240
SDKQQCWCRQ ALEQFNQLSQ VLHRLSLLER VCAEAVTTTL HQVTRERMED RCRGEYERSF 300
LREFHKWIER VVGWLGKVFL QDNPTRPTSP EAGNTLRRWR CHVQRFFYRI YATLRIEELF 360
SIIRDFPDSR PAIEDLKYCL ERTDQRQQLL VSLKVALETR LLHPGVNTCD IITLYISAIK 420
ALRVLDPSMV ILEVACEPIR RYLRTREDTV RQIVAGLTGD SDGTGDLAVE LSKTDPACLE 480
TGQDSEDDSG EPEDWVPDPV DADPVKSSSK RRSSDIISLL VSIYGSKDLF INEYRSLLAD 540
RLLHQFSFSP EREIRNVELL KLRFGEAPMH FCEVMLKDMA DSRRINANIR EEDEKRPVEE 600
QPPFGVYAVI LSSEFWPPFK DEKLEVPEDI RAALDVYCKK YEKLKAMRTL SWKHTLGLVT 660
MDVELADRTL SVAVTPVQAV VLLYFQNQAS WTLEELSKVV KMPVALLRRR MSVWLQQGVL 720
REEPPGTFSV IEEERPQDRD NMVLIDSDDE SDSGMASQAD QKEEELLLFW AYIQAMLTNL 780
ESLSLERIYS MLRMFVMTGP ALAEIDLQEL QGYLQKKVRD QQLIYSAGVY RLPKNSN 837 |
Gene Ontology | GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0007399; P:nervous system development; IEA:UniProtKB-KW. GO:0090129; P:positive regulation of synapse maturation; IDA:UniProtKB. GO:0031915; P:positive regulation of synaptic plasticity; IDA:UniProtKB. GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |