UniProt Accession

 MEMO1_MOUSE; Q91VH6 

Genbank Protein ID

 AF363447; BC013819 

Genbank Nucleotide ID

 AAL34463.1; AAH13819.1 

Protein Name

 Protein MEMO1 

Protein Synonyms/Alias

 Mediator of ErbB2-driven cell motility 1; Memo-1 

Gene Name

 Memo1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
108	YDLRIDQKIYGELWK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). 

Sequence Annotation

 MOD_RES 210 210 Phosphotyrosine.  

Keyword

 Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0042277; F:peptide binding; ISO:MGI.
 GO:0032886; P:regulation of microtubule-based process; ISS:UniProtKB. 

Interpro

 IPR002737; UPF0103/Memo-related. 

Pfam

 PF01875; Memo 

SMART

  

PROSITE

  

PRINTS