UniProt Accession

 LOC1_YEAST; P43586; D6VTN1 

Genbank Protein ID

 D50617; AY557809; BK006940 

Genbank Nucleotide ID

 BAA09240.1; AAS56135.1; DAA12441.1 

Protein Name

 60S ribosomal subunit assembly/export protein LOC1 

Protein Synonyms/Alias

 Localization of ASH1 mRNA protein 1 

Gene Name

 LOC1 

Gene Synonyms/Alias

 YFR001W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
73	KKGKYSEKDLNIPTL	acetylation	[1]
98	RRGKKGKKFIADNDT	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Required for efficient assembly and nuclear export of the 60S ribosomal subunit. Involved in asymmetric localization of ASH1 mRNA. 

Sequence Annotation

 MOD_RES 24 24 Phosphoserine.  

Keyword

 Coiled coil; Complete proteome; mRNA transport; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0030687; C:preribosome, large subunit precursor; IDA:SGD.
 GO:0003729; F:mRNA binding; IPI:SGD.
 GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0008298; P:intracellular mRNA localization; IMP:SGD.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0042273; P:ribosomal large subunit biogenesis; IPI:SGD. 

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