CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010054
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 GTPase obg 
Protein Synonyms/Alias
 GTP-binding protein obg 
Gene Name
 obg 
Gene Synonyms/Alias
 MPN_563; MP279 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
131GKGNAAFKSPIMRAPacetylation[1]
339LAQFGANKFHLPMEMacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (Potential). 
Sequence Annotation
 DOMAIN 171 283 G.
 NP_BIND 166 173 GTP (By similarity).
 NP_BIND 212 216 GTP (By similarity).
 NP_BIND 282 285 GTP (By similarity).  
Keyword
 Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 433 AA 
Protein Sequence
MGLTDYCECR FSAGNGGNGI IAWRREAHYD KGGPGGGNGG NGGNVVLQAD HNCDSLFFLK 60
NKKHLFAESG GNGKPDLAHG KNGEDLVIKV PVGTTVRDLD TNQILMDFVH DQQSFILCYG 120
GKGGKGNAAF KSPIMRAPNL YENGDKGQSL HVSLEIKYLA NVGIVGFPNT GKSTLISKLS 180
NAKPKIANYR FTTLVPVLGV VKHNDQSLVF ADIPGLIENA SEGSGLGHYF LRHIERCEIL 240
IHLISLDPVD HDDPCQAYEQ IMRELSKYSQ LLVKKKMLVV ANKTDVDLDG TRFQKLAQYL 300
ENKGIPLFKI SALKQELGDL VAQVFALHQK TLAQFGANKF HLPMEMEKHY VFEQASETDH 360
DPLNIERDAL GRWHVECKRL HYWFDKIPQT TLDNIRRLGN KIKEVGIEDQ LKVAGAKKGD 420
VIVFAGQEFV IND 433 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:HAMAP.
 GO:0003924; F:GTPase activity; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR014100; GTP-bd_Obg/CgtA.
 IPR015349; GTP-bd_prot_GTP1/OBG_C.
 IPR006074; GTP1-OBG_CS.
 IPR006169; GTP1_OBG_dom.
 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase. 
Pfam
 PF09269; DUF1967
 PF01018; GTP1_OBG
 PF01926; MMR_HSR1 
SMART
  
PROSITE
 PS00905; GTP1_OBG 
PRINTS
 PR00326; GTP1OBG.