| Tag | Content |
|---|
| CPLM ID | CPLM-010370 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chaperone protein DnaJ |
Protein Synonyms/Alias | |
Gene Name | dnaJ |
Gene Synonyms/Alias | MPN_021; MP133 |
Created Date | July 27, 2013 |
Organism | Mycoplasma pneumoniae (strain ATCC 29342 / M129) |
NCBI Taxa ID | 272634 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 24 | SATAQDIKRAFRKLA | acetylation | [1] | | 378 | IKPNQEVKQYLNALK | acetylation | [1] | | 385 | KQYLNALKNEYKS** | acetylation | [1] |
|
Reference | [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium. van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC. Mol Syst Biol. 2012 Feb 28;8:571. [ PMID: 22373819] |
Functional Description | Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity). |
Sequence Annotation | DOMAIN 5 79 J.
REPEAT 165 172 CXXCXGXG motif.
REPEAT 183 190 CXXCXGXG motif.
REPEAT 209 216 CXXCXGXG motif.
REPEAT 223 230 CXXCXGXG motif.
ZN_FING 152 235 CR-type.
METAL 165 165 Zinc 1 (By similarity).
METAL 168 168 Zinc 1 (By similarity).
METAL 183 183 Zinc 2 (By similarity).
METAL 186 186 Zinc 2 (By similarity).
METAL 209 209 Zinc 2 (By similarity).
METAL 212 212 Zinc 2 (By similarity).
METAL 223 223 Zinc 1 (By similarity).
METAL 226 226 Zinc 1 (By similarity). |
Keyword | Chaperone; Complete proteome; Cytoplasm; DNA replication; Metal-binding; Reference proteome; Repeat; Stress response; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 390 AA |
Protein Sequence | MAAGKRDYYE VLGVSRSATA QDIKRAFRKL AMQYHPDRHK GEGETVQKQN EEKFKEVNEA 60
YEVLSDTEKR GMYDRFGHEG LNASGFHETG FNPFDIFNSV FGEGFSFDMD GGSPFDFIFS 120
RGKKSRQNRV VLPYDLEIAV GVDISFFEMT NGCTRTIEYT KRVTCSACDG FGAEGGETGM 180
VSCNSCEGNG FILKNQRSIF GTVQSQMLCQ SCGGQGKQAK HKCKTCKGSK YKKVPTTKEI 240
QIPAGIYHGD ALVDDHGGNE FGGHVGKLVV HVGVLPSKIF KRVDHNVVAN VLVDPMIAIT 300
GGKIELPTLE GIKEFNLRAG TKSGEQIVIP GGGIKFTKNF RKKAGDLIII ISYARPSEYS 360
APELRKLKEF IKPNQEVKQY LNALKNEYKS 390 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |