CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007104
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-complex protein 1 subunit zeta 
Protein Synonyms/Alias
 TCP-1-zeta; CCT-zeta 
Gene Name
 CCT6 
Gene Synonyms/Alias
 TCP20; TCP6; YDR188W; YD9395.21 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
40LETNLGPKGTLKMLVubiquitination[1]
137MKFLDEFKISKTNLSacetylation[2]
392HYALAQTKDAVRDGLacetylation[2]
542RAGRSTLKETPQ***ubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation. 
Sequence Annotation
 MOD_RES 249 249 Phosphoserine.  
Keyword
 3D-structure; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 546 AA 
Protein Sequence
MSLQLLNPKA ESLRRDAALK VNVTSAEGLQ SVLETNLGPK GTLKMLVDGA GNIKLTKDGK 60
VLLTEMQIQS PTAVLIARAA AAQDEITGDG TTTVVCLVGE LLRQAHRFIQ EGVHPRIITD 120
GFEIARKESM KFLDEFKISK TNLSNDREFL LQVARSSLLT KVDADLTEVL TPIVTDAVLS 180
VYDAQADNLD LHMVEIMQMQ HLSPKDTTFI KGLVLDHGGR HPDMPTRVKN AYVLILNVSL 240
EYEKTEVNSG FFYSSADQRD KLAASERKFV DAKLKKIIDL KNEVCGMDPD KGFVIINQKG 300
IDPMSLDVFA KHNILALRRA KRRNMERLQL VTGGEAQNSV EDLSPQILGF SGLVYQETIG 360
EEKFTYVTEN TDPKSCTILI KGSTHYALAQ TKDAVRDGLR AVANVLKDKN IIPGAGAFYI 420
ALSRYLRSAN MNKLGAKGKT KTGIEAFAEA LLVIPKTLVK NSGFDPLDVL AMVEDELDDA 480
QDSDETRYVG VDLNIGDSCD PTIEGIWDSY RVLRNAITGA TGIASNLLLC DELLRAGRST 540
LKETPQ 546 
Gene Ontology
 GO:0005832; C:chaperonin-containing T-complex; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051082; F:unfolded protein binding; IDA:SGD.
 GO:0006457; P:protein folding; IDA:SGD. 
Interpro
 IPR012722; Chap_CCT_zeta.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.