UniProt Accession

 GPC3_HUMAN; P51654; C9JLE3; G3V1R0; Q2L880; Q2L882 

Genbank Protein ID

 U50410; L47124; L47125; L47176; Z37987; DQ349136; DQ349138; AL008712; AC002420; AF003529; AL009174; Z99570; AL009174; AC002420; AF003529; AL008712; Z99570; Z99570; AC002420; AF003529; AL008712; AL009174; AL034401; AL662851; Z97196; CH471107; AF003529 

Genbank Nucleotide ID

 AAA93471.1; AAA98131.1; AAA98132.1; AAB58806.1; CAA86069.1; ABC72125.1; ABC72127.1; CAI43110.1; CAI43110.1; CAI43110.1; CAI43110.1; CAI43110.1; CAI42761.1; CAI42761.1; CAI42761.1; CAI42761.1; CAI42761.1; CAI42277.1; CAI42277.1; CAI42277.1; CAI42277.1; CAI42277.1; EAX11771.1; AAB87062.1 

Protein Name

 Glypican-3 

Protein Synonyms/Alias

 GTR2-2; Intestinal protein OCI-5; MXR7; Secreted glypican-3 

Gene Name

 GPC3 

Gene Synonyms/Alias

 OCI5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
50	QRLQPGLKWVPETPV	ubiquitination	[1]
465	VVSQIIDKLKHINQL	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. 

Sequence Annotation

 CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).
 CARBOHYD 241 241 N-linked (GlcNAc...) (Potential).
 CARBOHYD 418 418 N-linked (GlcNAc...) (Potential).
 CARBOHYD 495 495 O-linked (Xyl...) (heparan sulfate)
 CARBOHYD 509 509 O-linked (Xyl...) (heparan sulfate)  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Disease mutation; Glycoprotein; GPI-anchor; Heparan sulfate; Lipoprotein; Membrane; Protease inhibitor; Proteoglycan; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 580 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
 GO:0005796; C:Golgi lumen; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0043202; C:lysosomal lumen; TAS:Reactome.
 GO:0005578; C:proteinaceous extracellular matrix; IEA:InterPro.
 GO:0060422; F:peptidyl-dipeptidase inhibitor activity; IDA:UniProtKB.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0030204; P:chondroitin sulfate metabolic process; TAS:Reactome.
 GO:0006024; P:glycosaminoglycan biosynthetic process; TAS:Reactome.
 GO:0006027; P:glycosaminoglycan catabolic process; TAS:Reactome.
 GO:0072138; P:mesenchymal cell proliferation involved in ureteric bud development; ISS:UniProtKB.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome. 

Interpro

 IPR001863; Glypican.
 IPR015501; Glypican-3.
 IPR019803; Glypican_CS. 

Pfam

 PF01153; Glypican 

SMART

  

PROSITE

 PS01207; GLYPICAN 

PRINTS