CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045605
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Complement C3 
Protein Synonyms/Alias
 RCG45082 
Gene Name
 C3 
Gene Synonyms/Alias
 rCG_45082 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
465SVSRVELKPGDNLNVacetylation[1]
485TDAGQEAKIRYYTYLacetylation[1]
606KGVFVLNKKNKLTQSacetylation[1]
681LMERRMDKAGQYTDKacetylation[1]
930DGVKKILKVVPEGMRacetylation[1]
1050QEALELIKKGYTQQLacetylation[1]
1215TKFLNTAKDRNRWEEacetylation[1]
1436ISKYEMDKAFSNKNTacetylation[1]
1595VKCRNALKLQKGKQYacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Reference proteome; Secreted. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1663 AA 
Protein Sequence
MGPTSGSQLL VLLLLLASSL LALGSPMYSI ITPNVLRLES EETFILEAHD AQGDVPVTVT 60
VQDFLKKQVL TSEKTVLTGA TGHLNRVSIK IPASKEFNAD KGHKYVTVVA NFGATVVEKA 120
VLVSFQSGYL FIQTDKTIYT PGSTVFYRIF TVDNNLLPVG KTVVIVIETP DGVPIKRDIL 180
SSHNQYGILP LSWNIPELVN MGQWKIRAFY EHAPKQTFSA EFEVKEYVLP SFEVLVEPTE 240
KFYYIDDPKG LEVSITARFL YGKNVDGTAF VIFGVQDEDK KISLAQSLTR VLIEDGSGEA 300
VLSRKVLMDG VRPSSPEALV GKSLYVSVTV ILHSGSDMVE AERSGIPIVT SPYQIHFTKT 360
PKFFKPAMPF DLMVFVTNPD GSPARRVPVV TQGSDAQALT QDDGVAKLSV NTPNNRQPLT 420
ITVRTKKEGI PDARQATRTM QAQPYSTMHN SNNYLHLSVS RVELKPGDNL NVNFHLRTDA 480
GQEAKIRYYT YLVMNKGKLL KAGRQVREPG QDLVVLSLPI TPEFIPSFRL VAYYTLIGAN 540
GQREVVADSV WVDVKDSCVG TLVVKGDPRD NRQPAPGHQT TLRIEGNQGA RVGLVAVDKG 600
VFVLNKKNKL TQSKIWDVVE KADIGCTPGS GKNYAGVFMD AGLTFKTNQG LQTDQREDPE 660
CAKPAARRRR SVQLMERRMD KAGQYTDKGL RKCCEDGMRD IPMKYSCQRR ARLITQGESC 720
LKAFMDCCNY ITKLREQHRR DHVLGLARSD VDEDIIPEED IISRSHFPES WLWTIEELKE 780
PEKNGISTKV MNIFLKDSIT TWEILAVSLS DKKGICVADP YEITVMQDFF IDLRLPYSVV 840
RNEQVEIRAV LFNYREQEKL KVRVELLHNP AFCSMATAKK RYYQTIEIPP KSSVAVPYVI 900
VPLKIGLQEV EVKAAVFNHF ISDGVKKILK VVPEGMRVNK TVAVRTLDPE HLGQGGVQRE 960
DVPAADLSDQ VPDTDSETRI LLQGTPVAQM AEDAVDGERL KHLIVTPSGC GEQNMIGMTP 1020
TVIAVHYLDQ TEQWEKFGLE KRQEALELIK KGYTQQLAFK QPSSAYAAFN NRPPSTWLTA 1080
YVVKVFSLAA NLIAIDSQVL CGAVKWLILE KQKPDGVFQE DGPVIHQEMI GGFRNTKEAD 1140
VSLTAFVLIA LQEARDICEG QVNSLPGSIN KAGEYLEASY LNLQRPYTVA IAGYALALMN 1200
KLEEPYLTKF LNTAKDRNRW EEPGQQLYNV EATSYALLAL LLLKDFDSVP PVVRWLNEQR 1260
YYGGGYGSTQ ATFMVFQALA QYQTDVPDHK DLNMDVSLHL PSRSSPTVFR LLWESGSLLR 1320
SEETKQNEGF SLTAKGKGQG TLSVVTVYHA KVKGKATCKK FDLRVTIKPA PETAKKPQDA 1380
KSSMILDICT RYLGDVDATM SILDISMMTG FIPDTNDLEL LSSGVDRYIS KYEMDKAFSN 1440
KNTLIIYLEK ISHSEEDCLS FKVHQFFNVG LIQPGSVKVY SYYNLEESCT RFYHPEKDDG 1500
MLSKLCHNEM CRCAEENCFM HQSQDQVSLN ERLDKACEPG VDYVYKTKLT TIELSDDFDE 1560
YIMTIEQVIK SGSDEVQAGQ ERRFISHVKC RNALKLQKGK QYLMWGLSSD LWGEKPNTSY 1620
IIGKDTWVEH WPEAEECQDQ KNQKQCEDLG AFTETMVVFG CPN 1663 
Gene Ontology
 GO:0005615; C:extracellular space; IEA:InterPro.
 GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
 GO:0006956; P:complement activation; IEA:InterPro.
 GO:0006954; P:inflammatory response; IEA:InterPro.
 GO:0010951; P:negative regulation of endopeptidase activity; IEA:GOC. 
Interpro
 IPR009048; A-macroglobulin_rcpt-bd.
 IPR011626; A2M_comp.
 IPR002890; A2M_N.
 IPR011625; A2M_N_2.
 IPR000020; Anaphylatoxin/fibulin.
 IPR018081; Anaphylatoxin_.
 IPR001840; Anaphylatoxn.
 IPR001599; Macroglobln_a2.
 IPR019742; MacrogloblnA2_CS.
 IPR019565; MacrogloblnA2_thiol-ester-bond.
 IPR001134; Netrin_domain.
 IPR018933; Netrin_module_non-TIMP.
 IPR008930; Terpenoid_cyclase/PrenylTrfase.
 IPR008993; TIMP-like_OB-fold. 
Pfam
 PF00207; A2M
 PF07678; A2M_comp
 PF01835; A2M_N
 PF07703; A2M_N_2
 PF07677; A2M_recep
 PF01821; ANATO
 PF01759; NTR
 PF10569; Thiol-ester_cl 
SMART
 SM00104; ANATO
 SM00643; C345C 
PROSITE
 PS00477; ALPHA_2_MACROGLOBULIN
 PS01177; ANAPHYLATOXIN_1
 PS01178; ANAPHYLATOXIN_2
 PS50189; NTR 
PRINTS
 PR00004; ANAPHYLATOXN.