UniProt Accession

 VAMP4_HUMAN; O75379; A2IDD8; Q96IY9; Q96J20; Q9UEL7 

Genbank Protein ID

 AF044310; AL035296; Z98751; CH471067; BC005974; BC007019; BC031264 

Genbank Nucleotide ID

 AAC24032.1; CAA22896.1; CAM28272.1; EAW90904.1; AAH05974.1; AAH07019.1; AAH31264.1 

Protein Name

 Vesicle-associated membrane protein 4 

Protein Synonyms/Alias

 VAMP-4 

Gene Name

 VAMP4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MPPKFKRHLND	ubiquitination	[1]
19	DDVTGSVKSERRNLL	ubiquitination	[1]
86	RLDELQDKSESLSDN	ubiquitination	[1]
114	QMWWRGCKIKAIMAL	ubiquitination	[1]
116	WWRGCKIKAIMALVA	ubiquitination	[1]
137	IIILIVMKYRT****	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. 

Sequence Annotation

 DOMAIN 52 112 v-SNARE coiled-coil homology.
 MOD_RES 17 17 Phosphoserine (By similarity).
 MOD_RES 30 30 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 141 AA 

Protein Sequence

Gene Ontology

 GO:0005768; C:endosome; TAS:ProtInc.
 GO:0000139; C:Golgi membrane; TAS:ProtInc.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005764; C:lysosome; TAS:ProtInc.
 GO:0031201; C:SNARE complex; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Compara.
 GO:0042996; P:regulation of Golgi to plasma membrane protein transport; IEA:Compara. 

Interpro

 IPR001388; Synaptobrevin.
 IPR016444; Synaptobrevin_met/fun. 

Pfam

 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.