CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037241
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Chromosome transmission fidelity protein 18 homolog 
Protein Synonyms/Alias
  
Gene Name
 CHTF18 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
425VSLASLKKQVDGERRubiquitination[1]
563PSQRPKQKVALLCGPubiquitination[1]
650LLSILNRKGPQEVGPubiquitination[1, 2, 3]
734VLAALCEKTDNDIRAubiquitination[1, 4]
1050KPLTYQTKQLIAREIubiquitination[1, 5]
1061AREIEVEKMRRAEASubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1184 AA 
Protein Sequence
MHVNASARRW GRGGAAALPG PAASPRRPAP RTGPVGRPTL APSPSRAHAH AKTNLLPGRA 60
VQAPDAVPGA GSSRAPARWR PRDPGSSAPD AWQRFRPAPL RAQPRPPPRP APGPPPPRKG 120
GCGGQWRAPQ DRTRGLRSRN SPRPPLAQPR LRHANQWRAP PGTPAADWRR PARSGRAVRD 180
GGGGAGGSER ELGLADGMED YEQELCGVED DFHNQFAAEL EVLAELEGAS TPSPSGVPLF 240
TAGRPPRTFE EALARGDAAS SPAPAASVGS SQGGARKRQV DADLQPAGSL PHAPRIKRPR 300
LQVVKRLNFR SEEMEEPPPP DSSPTDITPP PSPEDLAELW GHGFSEAAAD VGLTRASPAA 360
RNPVLRRPPI LEDYVHVTST EGVRAYLVLR ADPMAPGVQG SLLHVPWRGG GQLDLLGVSL 420
ASLKKQVDGE RRERLLQEAQ KLSDTLHRSG EEEAAQPLGA PEEEPTDGQD ASSHCLWVDE 480
FAPRHYTELL SDDFTNRCLL KWLKLWDLVV FGHERPSRKP RPSVEPARVS KEATAPGKWK 540
SHEQVLEEML EAGLDPSQRP KQKVALLCGP PGLGKTTLAH VIARHAGYSV VEMNASDDRS 600
PEVFRTRIEA ATQMESVLGA GGKPNCLVID EIDGAPVAAI NVLLSILNRK GPQEVGPQGP 660
AVPSGGGRRR RAEGGLLMRP IICICNDQFA PSLRQLKQQA FLLHFPPTLP SRLVQRLQEG 720
MRADPGVLAA LCEKTDNDIR ACINTLQFLY SRGQRELSVR DVQATRVGLK DQRRGLFSVW 780
QEVFQLPRAQ RSSQHVSVLT CHGTPGDAGL VVLQDMGDAG LGLWDVLLLA WTRRGTFPGR 840
FYRVLHAAAS AGEHEKVVQG LFDNFLRLRL RDSSLGAVCV ALDWLAFDDL LAGAAHHSQS 900
FQLLRYPPFL PVAFHVLFAS SHTPRITFPS SQQEAQNRMS QMRNLIQTLV SGIAPATRSR 960
ATPQALLLDA LCLLLDILAP KLRPVSTQLY STREKQQLAS LVGTMLAYSL TYRQERTPDG 1020
QYIYRLEPNV EELCRFPELP ARKPLTYQTK QLIAREIEVE KMRRAEASAR VENSPQVDGS 1080
PPGLEGLLGG IGEKGVHRPA PRNHEQRLEH IMRRAAREEQ PEKDFFGRVV VRSTAVPSAG 1140
DTAPEQDSVE RRMGTAVGRS EVWFRFNEGV SNAVRRSLYI RDLL 1184 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS