| Tag | Content |
|---|
| CPLM ID | CPLM-012229 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily C member 3 |
Protein Synonyms/Alias | KSHIIID; Voltage-gated potassium channel subunit Kv3.3 |
Gene Name | KCNC3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 243 | DGAGGELKRLCFQDA | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
Sequence Annotation | MOTIF 503 508 Selectivity filter (By similarity).
CARBOHYD 320 320 N-linked (GlcNAc...) (Potential).
CARBOHYD 336 336 N-linked (GlcNAc...) (Potential).
CARBOHYD 483 483 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Disease mutation; Glycoprotein; Ion channel; Ion transport; Membrane; Neurodegeneration; Potassium; Potassium channel; Potassium transport; Reference proteome; Spinocerebellar ataxia; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 757 AA |
Protein Sequence | MLSSVCVSSF RGRQGASKQQ PAPPPQPPES PPPPPLPPQQ QQPAQPGPAA SPAGPPAPRG 60
PGDRRAEPCP GLPAAAMGRH GGGGGDSGKI VINVGGVRHE TYRSTLRTLP GTRLAGLTEP 120
EAAARFDYDP GADEFFFDRH PGVFAYVLNY YRTGKLHCPA DVCGPLFEEE LGFWGIDETD 180
VEACCWMTYR QHRDAEEALD SFEAPDPAGA ANAANAAGAH DGGLDDEAGA GGGGLDGAGG 240
ELKRLCFQDA GGGAGGPPGG AGGAGGTWWR RWQPRVWALF EDPYSSRAAR YVAFASLFFI 300
LISITTFCLE THEGFIHISN KTVTQASPIP GAPPENITNV EVETEPFLTY VEGVCVVWFT 360
FEFLMRITFC PDKVEFLKSS LNIIDCVAIL PFYLEVGLSG LSSKAAKDVL GFLRVVRFVR 420
ILRIFKLTRH FVGLRVLGHT LRASTNEFLL LIIFLALGVL IFATMIYYAE RIGADPDDIL 480
GSNHTYFKNI PIGFWWAVVT MTTLGYGDMY PKTWSGMLVG ALCALAGVLT IAMPVPVIVN 540
NFGMYYSLAM AKQKLPKKKN KHIPRPPQPG SPNYCKPDPP PPPPPHPHHG SGGISPPPPI 600
TPPSMGVTVA GAYPAGPHTH PGLLRGGAGG LGIMGLPPLP APGEPCPLAQ EEVIEINRAD 660
PRPNGDPAAA ALAHEDCPAI DQPAMSPEDK SPITPGSRGR YSRDRACFLL TDYAPSPDGS 720
IRKATGAPPL PPQDWRKPGP PSFLPDLNAN AAAWISP 757 |
Gene Ontology | GO:0030673; C:axolemma; IEA:Compara. GO:0043679; C:axon terminus; IEA:Compara. GO:0032590; C:dendrite membrane; IEA:Compara. GO:0031594; C:neuromuscular junction; IEA:Compara. GO:0032809; C:neuronal cell body membrane; IEA:Compara. GO:0008076; C:voltage-gated potassium channel complex; TAS:ProtInc. GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome. GO:0008219; P:cell death; IEA:UniProtKB-KW. GO:0051260; P:protein homooligomerization; IEA:InterPro. GO:0046928; P:regulation of neurotransmitter secretion; IEA:Compara. GO:0007268; P:synaptic transmission; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |