CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003376
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lipid A biosynthesis lauroyl acyltransferase 
Protein Synonyms/Alias
 Heat shock protein B 
Gene Name
 htrB 
Gene Synonyms/Alias
 waaM; b1054; JW1041 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
180NKSMLDRKDLKGMIKacetylation[1]
183MLDRKDLKGMIKALKacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA. Has 10 fold selectivity for lauroyl- ACP over myristoyl-ACP. 
Sequence Annotation
  
Keyword
 Acyltransferase; Cell inner membrane; Cell membrane; Complete proteome; Lipopolysaccharide biosynthesis; Membrane; Reference proteome; Stress response; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 306 AA 
Protein Sequence
MTNLPKFSTA LLHPRYWLTW LGIGVLWLVV QLPYPVIYRL GCGLGKLALR FMKRRAKIVH 60
RNLELCFPEM SEQERRKMVV KNFESVGMGL METGMAWFWP DRRIARWTEV IGMEHIRDVQ 120
AQKRGILLVG IHFLTLELGA RQFGMQEPGI GVYRPNDNPL IDWLQTWGRL RSNKSMLDRK 180
DLKGMIKALK KGEVVWYAPD HDYGPRSSVF VPLFAVEQAA TTTGTWMLAR MSGACLVPFV 240
PRRKPDGKGY QLIMLPPECS PPLDDAETTA AWMNKVVEKC IMMAPEQYMW LHRRFKTRPE 300
GVPSRY 306 
Gene Ontology
 GO:0009276; C:Gram-negative-bacterium-type cell wall; IEA:InterPro.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:EcoliWiki.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0016740; F:transferase activity; IDA:EcoliWiki.
 GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
 GO:0036104; P:Kdo2-lipid A biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009245; P:lipid A biosynthetic process; IMP:EcoliWiki.
 GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:InterPro.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR004960; LipA_acyltrans.
 IPR011920; Lipid_A_HtrB. 
Pfam
 PF03279; Lip_A_acyltrans 
SMART
  
PROSITE
  
PRINTS