CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014365
UniProt Accession
Genbank Protein ID
 M96827 
Genbank Nucleotide ID
Protein Name
 Haptoglobin 
Protein Synonyms/Alias
 Zonulin; Haptoglobin alpha chain; Haptoglobin beta chain 
Gene Name
 Hp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
111IGGSMDAKGSFPWQAubiquitination[1]
119GSFPWQAKMISRHGLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity). 
Sequence Annotation
 DOMAIN 31 88 Sushi.
 DOMAIN 103 345 Peptidase S1.
 REGION 259 264 Interaction with CD163 (By similarity).
 CARBOHYD 148 148 N-linked (GlcNAc...).
 CARBOHYD 182 182 N-linked (GlcNAc...).
 CARBOHYD 256 256 N-linked (GlcNAc...).
 CARBOHYD 264 264 N-linked (GlcNAc...) (Potential).
 DISULFID 33 33 Interchain (By similarity).
 DISULFID 52 86 By similarity.
 DISULFID 90 207 Interchain (between alpha and beta
 DISULFID 250 281 By similarity.
 DISULFID 292 322 By similarity.  
Keyword
 Acute phase; Antibiotic; Antimicrobial; Antioxidant; Complete proteome; Disulfide bond; Glycoprotein; Hemoglobin-binding; Immunity; Reference proteome; Secreted; Serine protease homolog; Signal; Sushi. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 347 AA 
Protein Sequence
MRALGAVVTL LLWGQLFAVE LGNDAMDFED DSCPKPPEIA NGYVEHLVRY RCRQFYRLRA 60
EGDGVYTLND EKQWVNTVAG EKLPECEAVC GKPKHPVDQV QRIIGGSMDA KGSFPWQAKM 120
ISRHGLTTGA TLISDQWLLT TAKNLFLNHS ETASAKDITP TLTLYVGKNQ LVEIEKVVLH 180
PNHSVVDIGL IKLKQRVLVT ERVMPICLPS KDYIAPGRVG YVSGWGRNAN FRFTDRLKYV 240
MLPVADQDKC VVHYENSTVP EKKNLTSPVG VQPILNEHTF CAGLTKYQED TCYGDAGSAF 300
AIHDMEEDTW YAAGILSFDK SCAVAEYGVY VRATDLKDWV QETMAKN 347 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016209; F:antioxidant activity; IEA:UniProtKB-KW.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
 GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0033590; P:response to cobalamin; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0033591; P:response to L-ascorbic acid; IEA:Compara.
 GO:0010288; P:response to lead ion; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0032026; P:response to magnesium ion; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR008292; Haptoglobin.
 IPR001254; Peptidase_S1.
 IPR001314; Peptidase_S1A.
 IPR000436; Sushi_SCR_CCP.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF00089; Trypsin 
SMART
 SM00032; CCP
 SM00020; Tryp_SPc 
PROSITE
 PS50923; SUSHI
 PS50240; TRYPSIN_DOM 
PRINTS
 PR00722; CHYMOTRYPSIN.