UniProt Accession

 ZN143_HUMAN; P52747; A8K518; B4DLY5; O75559; Q8WUK9 

Genbank Protein ID

 AK291133; AK297214; AC127030; AC132192; BC020219; U09850; AF071771 

Genbank Nucleotide ID

 BAF83822.1; BAG59697.1; AAH20219.1; AAC50266.1; AAC96102.1 

Protein Name

 Zinc finger protein 143 

Protein Synonyms/Alias

 SPH-binding factor; Selenocysteine tRNA gene transcription-activating factor; hStaf 

Gene Name

 ZNF143 

Gene Synonyms/Alias

 SBF; STAF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
71	QHNSKDAKLIDGQVI	ubiquitination	[1]
95	VQHVPIPKSTGDSLR	ubiquitination	[1]
246	CEYDGCGKLYTTAHH	ubiquitination	[1]
255	YTTAHHLKVHERSHT	ubiquitination	[1]
276	CEHAGCGKAFATGYG	ubiquitination	[1]
285	FATGYGLKSHVRTHT	ubiquitination	[1, 2]
295	VRTHTGEKPYRCSED	acetylation	[3]
306	CSEDNCTKSFKTSGD	ubiquitination	[1]
328	HTGERPFKCPFEGCG	ubiquitination	[1]
375	FASATNYKNHVRIHT	ubiquitination	[1]
385	VRIHTGEKPYVCTVP	ubiquitination	[1]
396	CTVPGCDKRFTEYSS	ubiquitination	[1]
436	ISTLAMHKRTAHNDT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 

Functional Description

 Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8. 

Sequence Annotation

 ZN_FING 237 261 C2H2-type 1.
 ZN_FING 267 291 C2H2-type 2.
 ZN_FING 297 321 C2H2-type 3.
 ZN_FING 327 351 C2H2-type 4.
 ZN_FING 357 381 C2H2-type 5.
 ZN_FING 387 411 C2H2-type 6.
 ZN_FING 417 440 C2H2-type 7.  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 638 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006359; P:regulation of transcription from RNA polymerase III promoter; TAS:ProtInc.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006383; P:transcription from RNA polymerase III promoter; TAS:Reactome. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS