CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018290
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 480 
Protein Synonyms/Alias
  
Gene Name
 ZNF480 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53PAQRALYKDVMLENYubiquitination[1]
93WSGESEVKIAKNSDGubiquitination[1]
125NAEDKPIKKQLGVSFubiquitination[1]
126AEDKPIKKQLGVSFHubiquitination[1]
285QRIHTREKPYECNECubiquitination[1]
294YECNECGKVFSNNSYubiquitination[1]
327CGKGFSHKSSLANHWubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in transcriptional regulation as an activator. 
Sequence Annotation
 DOMAIN 27 98 KRAB.
 ZN_FING 203 225 C2H2-type 1; atypical.
 ZN_FING 231 253 C2H2-type 2.
 ZN_FING 259 281 C2H2-type 3.
 ZN_FING 287 309 C2H2-type 4.
 ZN_FING 315 337 C2H2-type 5; degenerate.
 ZN_FING 343 365 C2H2-type 6.
 ZN_FING 371 393 C2H2-type 7.
 ZN_FING 399 421 C2H2-type 8.
 ZN_FING 427 449 C2H2-type 9.
 ZN_FING 455 477 C2H2-type 10.
 ZN_FING 483 505 C2H2-type 11.
 ZN_FING 511 533 C2H2-type 12.  
Keyword
 Activator; Alternative splicing; Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 535 AA 
Protein Sequence
MLCDEKAQKR RKRKAKESGM ALPQGHLTFR DVAIEFSQAE WKCLDPAQRA LYKDVMLENY 60
RNLVSLGISL PDLNINSMLE QRREPWSGES EVKIAKNSDG RECIKGVNTG SSYALGSNAE 120
DKPIKKQLGV SFHLHLSELE LFPDERVING CNQVENFINH SSSVSCLQEM SSSVKTPIFN 180
RNDFDDSSFL PQEQKVHLRE KPYECNEHSK VFRVSSSLTK HQVIHTVEKP YKCNSCGKVF 240
SRNSHLAEHC RIHTGEKPYK CNVCGKVFSY NSNFARHQRI HTREKPYECN ECGKVFSNNS 300
YLARHQRIHA EEKPYKCNEC GKGFSHKSSL ANHWRIYTGE KPYKCDECGK AFYRIALLVR 360
HQKIHTGEKP YKCNECGKVF IQNSHLAQHW RIHTGEKPYK CNECGKVFNQ LSNLARHRRI 420
HTGEKPYKCN ECGKAFSEYS GLSAHLVIHT GEKPYKCSEC GKAFRHKLSL TNHQRIHTGE 480
RPYKCNECGK VFNRIAHLAR HRKIHTGEKP YKCNECGKAF SRISYLAQHW TIHMG 535 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS