UniProt Accession

 NDKA_HUMAN; P15531; Q6FGK3; Q86XQ2; Q9UDJ6 

Genbank Protein ID

 X17620; X73066; X75598; AF487339; AK291105; CR542104; CR542115; AC005839; CH471109; BC000293; BC018994 

Genbank Nucleotide ID

 CAA35621.1; CAA51527.1; CAA53270.1; AAO85436.1; BAF83794.1; CAG46901.1; CAG46912.1; EAW94568.1; AAH00293.1; AAH18994.1 

Protein Name

 Nucleoside diphosphate kinase A 

Protein Synonyms/Alias

 NDK A; NDP kinase A; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; Tumor metastatic process-associated protein; nm23-H1 

Gene Name

 NME1 

Gene Synonyms/Alias

 NDPKA; NM23 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
37	ERTFIAIKPDGVQRG	ubiquitination	[1, 2]
51	GLVGEIIKRFEQKGF	ubiquitination	[1, 2]
56	IIKRFEQKGFRLVGL	ubiquitination	[2]
81	KEHYVDLKDRPFFAG	ubiquitination	[1, 2]
125	ETNPADSKPGTIRGD	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. 

Sequence Annotation

 ACT_SITE 118 118 Pros-phosphohistidine intermediate.
 BINDING 12 12 ATP.
 BINDING 60 60 ATP.
 BINDING 88 88 ATP.
 BINDING 94 94 ATP.
 BINDING 105 105 ATP.
 BINDING 115 115 ATP.
 MOD_RES 2 2 N-acetylalanine.
 CROSSLNK 100 100 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Endocytosis; Isopeptide bond; Kinase; Magnesium; Metal-binding; Neurogenesis; Nucleotide metabolism; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Transferase; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; TAS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0004536; F:deoxyribonuclease activity; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0004550; F:nucleoside diphosphate kinase activity; IDA:UniProtKB.
 GO:0043024; F:ribosomal small subunit binding; IPI:UniProtKB.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Compara.
 GO:0003697; F:single-stranded DNA binding; IEA:Compara.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0071398; P:cellular response to fatty acid; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEA:Compara.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; TAS:UniProtKB.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0002762; P:negative regulation of myeloid leukocyte differentiation; IEA:Compara.
 GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome.
 GO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:HGNC.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
 GO:0014075; P:response to amine stimulus; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0033574; P:response to testosterone stimulus; IEA:Compara.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 

Interpro

 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.