CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002796
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2',3'-cyclic-nucleotide 3'-phosphodiesterase 
Protein Synonyms/Alias
 CNP; CNPase 
Gene Name
 CNP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67MVSADAYKITPGARGubiquitination[1]
155QLSADDLKKLKPGLEubiquitination[1]
197LEELGNHKAFKKELRubiquitination[1]
241TKFCDYGKAPGAEEYubiquitination[2]
296LWPSDVDKLSPTDNLubiquitination[1, 2]
366RWMLTLAKNMEVRAIubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
 May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity). 
Sequence Annotation
 ACT_SITE 251 251 Proton acceptor.
 ACT_SITE 330 330 Proton donor.
 BINDING 253 253 Substrate.
 BINDING 332 332 Substrate.
 MOD_RES 110 110 Phosphotyrosine (By similarity).
 MOD_RES 373 373 Phosphotyrosine (By similarity).
 MOD_RES 418 418 Cysteine methyl ester (By similarity).
 LIPID 418 418 S-farnesyl cysteine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Lipoprotein; Membrane; Methylation; Phosphoprotein; Polymorphism; Prenylation; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 421 AA 
Protein Sequence
MSSSGAKDKP ELQFPFLQDE DTVATLLECK TLFILRGLPG SGKSTLARVI VDKYRDGTKM 60
VSADAYKITP GARGAFSEEY KRLDEDLAAY CRRRDIRILV LDDTNHERER LEQLFEMADQ 120
YQYQVVLVEP KTAWRLDCAQ LKEKNQWQLS ADDLKKLKPG LEKDFLPLYF GWFLTKKSSE 180
TLRKAGQVFL EELGNHKAFK KELRQFVPGD EPREKMDLVT YFGKRPPGVL HCTTKFCDYG 240
KAPGAEEYAQ QDVLKKSYSK AFTLTISALF VTPKTTGARV ELSEQQLQLW PSDVDKLSPT 300
DNLPRGSRAH ITLGCAADVE AVQTGLDLLE ILRQEKGGSR GEEVGELSRG KLYSLGNGRW 360
MLTLAKNMEV RAIFTGYYGK GKPVPTQGSR KGGALQSCTI I 401 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IDA:UniProtKB.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:Compara.
 GO:0035748; C:myelin sheath abaxonal region; IEA:Compara.
 GO:0035749; C:myelin sheath adaxonal region; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0031143; C:pseudopodium; IEA:Compara.
 GO:0004113; F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; TAS:ProtInc.
 GO:0030551; F:cyclic nucleotide binding; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0007409; P:axonogenesis; IEA:Compara.
 GO:0009214; P:cyclic nucleotide catabolic process; IEA:InterPro.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara.
 GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0016070; P:RNA metabolic process; IEA:InterPro.
 GO:0007268; P:synaptic transmission; TAS:ProtInc. 
Interpro
 IPR008431; CNPase.
 IPR027417; P-loop_NTPase.
 IPR009097; RNA_ligase/cNuc_Pdiesterase. 
Pfam
 PF05881; CNPase 
SMART
  
PROSITE
  
PRINTS