CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031163
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Engulfment and cell motility protein 2 
Protein Synonyms/Alias
 cDNA FLJ60834, highly similar to Engulfment and cell motility protein 2 (CED-12 homolog A) 
Gene Name
 ELMO2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
105ETRLDAMKELAKLSAubiquitination[1]
352APGSGTEKRKAMYTKubiquitination[1, 2]
354GSGTEKRKAMYTKDYubiquitination[1]
359KRKAMYTKDYKMLGFubiquitination[1]
413ENSSREDKHECPFGRacetylation[3]
413ENSSREDKHECPFGRubiquitination[3]
473QLLNKTWKEMRATAEubiquitination[1]
500ITRALPSKPNSLDQFubiquitination[1]
544PIVELREKIQPEILEubiquitination[1, 3, 4]
554PEILELIKQQRLNRLubiquitination[1, 3, 4]
589CRLALNHKVLHYGDLubiquitination[1]
612TFESLQEKIPVADIKubiquitination[1]
619KIPVADIKAIVTGKDubiquitination[1]
625IKAIVTGKDCPHMKEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 732 AA 
Protein Sequence
MPPPSDIVKV AIEWPGANAQ LLEIDQKRPL ASIIKEVCDG WSLPNPEYYT LRYADGPQLY 60
ITEQTRSDIK NGTILQLAIS PSRAARQLME RTQSSNMETR LDAMKELAKL SADVTFATEF 120
INMDGIIVLT RLVESGTKLL SHYSEMLAFT LTAFLELMDH GIVSWDMVSI TFIKQIAGYV 180
SQPMVDVSIL QRSLAILESM VLNSQSLYQK IAEEITVGQL ISHLQVSNQE IQTYAIALIN 240
ALFLKAPEDK RQDKHLNPLD LPVTDMANAF AQKHLRSIIL NHVIRGNRPI KTEMAHQLYV 300
LQVLTFNLLE ERMMTKMDPN DQAQRDIIFE LRRIAFDAES DPSNAPGSGT EKRKAMYTKD 360
YKMLGFTNHI NPAMDFTQTP PGMLALDNML YLAKVHQDTY IRIVLENSSR EDKHECPFGR 420
SAIELTKMLC EILQVGELPN EGRNDYHPMF FTHDRAFEEL FGICIQLLNK TWKEMRATAE 480
DFNKVMQVVR EQITRALPSK PNSLDQFKSK LRSLSYSEIL RLRQSERMSQ DDFQSPPIVE 540
LREKIQPEIL ELIKQQRLNR LCEGSSFRKI GNRRRQERFW YCRLALNHKV LHYGDLDDNP 600
QGEVTFESLQ EKIPVADIKA IVTGKDCPHM KEKSALKQNK EVLELAFSIL YDPDETLNFI 660
APNKYEYCIW IDGLSALLGK DMSSELTKSD LDTLLSMEMK LRLLDLENIQ IPEAPPPIPK 720
EPSSYDFVYH YG 732 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0006909; P:phagocytosis; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR024574; DUF3361.
 IPR006816; Engulfment_cell_motility_ELMO.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF11841; DUF3361
 PF04727; ELMO_CED12 
SMART
 SM00233; PH 
PROSITE
 PS51335; ELMO 
PRINTS