CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006596
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol phosphorylceramide synthase catalytic subunit AUR1 
Protein Synonyms/Alias
 IPC synthase catalytic subunit AUR1; Aureobasidin A resistance protein; Phosphatidylinositol:ceramide phosphoinositol transferase 
Gene Name
 AUR1 
Gene Synonyms/Alias
 YKL004W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
399SITSLGVKRA*****ubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis. 
Sequence Annotation
 MOD_RES 392 392 Phosphoserine.
 MOD_RES 395 395 Phosphoserine.
 CARBOHYD 132 132 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Golgi apparatus; Lipid metabolism; Membrane; Phosphoprotein; Reference proteome; Sphingolipid metabolism; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 401 AA 
Protein Sequence
MANPFSRWFL SERPPNCHVA DLETSLDPHQ TLLKVQKYKP ALSDWVHYIF LGSIMLFVFI 60
TNPAPWIFKI LFYCFLGTLF IIPATSQFFF NALPILTWVA LYFTSSYFPD DRRPPITVKV 120
LPAVETILYG DNLSDILATS TNSFLDILAW LPYGLFHFGA PFVVAAILFV FGPPTVLQGY 180
AFAFGYMNLF GVIMQNVFPA APPWYKILYG LQSANYDMHG SPGGLARIDK LLGINMYTTA 240
FSNSSVIFGA FPSLHSGCAT MEALFFCYCF PKLKPLFIAY VCWLWWSTMY LTHHYFVDLM 300
AGSVLSYVIF QYTKYTHLPI VDTSLFCRWS YTSIEKYDIS KSDPLAADSN DIESVPLSNL 360
ELDFDLNMTD EPSVSPSLFD GSTSVSRSSA TSITSLGVKR A 401 
Gene Ontology
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0070916; C:inositol phosphoceramide synthase complex; IPI:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0045140; F:inositol phosphoceramide synthase activity; IDA:SGD.
 GO:0006673; P:inositolphosphoceramide metabolic process; IDA:SGD.
 GO:0030148; P:sphingolipid biosynthetic process; IMP:SGD. 
Interpro
 IPR016118; P_Acid_Pase/Cl_peroxidase_N.
 IPR000326; P_Acid_Pase_2/haloperoxidase. 
Pfam
 PF01569; PAP2 
SMART
 SM00014; acidPPc 
PROSITE
  
PRINTS