UniProt Accession

 RNH2B_MOUSE; Q80ZV0; Q9D014 

Genbank Protein ID

 AK011914; AK082752; BC047997 

Genbank Nucleotide ID

 BAB27913.1; BAC38602.1; AAH47997.1 

Protein Name

 Ribonuclease H2 subunit B 

Protein Synonyms/Alias

 RNase H2 subunit B; Deleted in lymphocytic leukemia 8 homolog; Ribonuclease HI subunit B 

Gene Name

 Rnaseh2b 

Gene Synonyms/Alias

 Dleu8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
292	KVDKSGMKSIDAFFG	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. 

Sequence Annotation

 MOD_RES 292 292 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 308 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0032299; C:ribonuclease H2 complex; ISS:UniProtKB.
 GO:0004523; F:ribonuclease H activity; IDA:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0010629; P:negative regulation of gene expression; IMP:MGI.
 GO:0048146; P:positive regulation of fibroblast proliferation; IMP:MGI.
 GO:2000001; P:regulation of DNA damage checkpoint; IMP:MGI.
 GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IMP:MGI.
 GO:0009259; P:ribonucleotide metabolic process; IMP:MGI.
 GO:0006401; P:RNA catabolic process; ISS:UniProtKB. 

Interpro

 IPR019024; RNase_H2_suB. 

Pfam

 PF09468; RNase_H2-Ydr279 

SMART

  

PROSITE

  

PRINTS