UniProt Accession

 QORX_HUMAN; Q53FA7; D6W533; O14679; O14685; Q38G78; Q6JLE7; Q9BWB8 

Genbank Protein ID

 AF010309; AF010317; AY371700; BT007149; AK223382; DQ232851; AC008073; CH471053; CH471053; CH471053; BC000474 

Genbank Nucleotide ID

 AAC39528.1; AAC39535.1; AAQ90166.1; AAP35813.1; BAD97102.1; ABB02183.1; AAY14665.1; EAX00762.1; EAX00763.1; EAX00766.1; AAH00474.1 

Protein Name

 Quinone oxidoreductase PIG3 

Protein Synonyms/Alias

 Tumor protein p53-inducible protein 3; p53-induced gene 3 protein 

Gene Name

 TP53I3 

Gene Synonyms/Alias

 PIG3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
321	HKYMEANKNIGKIVL	acetylation	[1, 2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

 May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). 

Sequence Annotation

 NP_BIND 148 154 NADP.
 NP_BIND 173 177 NADP.
 NP_BIND 264 266 NADP.
 BINDING 41 41 NADP.
 BINDING 192 192 NADP.
 BINDING 322 322 NADP.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; NADP; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 332 AA 

Protein Sequence

Gene Ontology

 GO:0070402; F:NADPH binding; IDA:UniProtKB.
 GO:0003960; F:NADPH:quinone reductase activity; IDA:UniProtKB.
 GO:0048038; F:quinone binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; NAS:UniProtKB.
 GO:0006739; P:NADP metabolic process; IDA:UniProtKB. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom.
 IPR014189; Quinone_OxRdtase_PIG3. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS01162; QOR_ZETA_CRYSTAL 

PRINTS