UniProt Accession

 APT_MOUSE; P08030; Q564P4; Q61319; Q6PK77; Q9DCY3 

Genbank Protein ID

 M11310; AB033539; AB033540; AK002350; AK153201; AC114917; CH466525; BC005667; M86439 

Genbank Nucleotide ID

 AAA37255.1; BAD95571.1; BAD95572.1; BAB22029.1; BAE31801.1; EDL11692.1; AAH05667.1; AAA37256.1 

Protein Name

 Adenine phosphoribosyltransferase 

Protein Synonyms/Alias

 APRT 

Gene Name

 Aprt 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MSEPELKLVARRIR	acetylation	[1]
34	RDISPLLKDPDSFRA	acetylation	[1, 2]
34	RDISPLLKDPDSFRA	ubiquitination	[3]
51	RLLASHLKSTHSGKI	acetylation	[1]
57	LKSTHSGKIDYIAGL	acetylation	[1]
57	LKSTHSGKIDYIAGL	ubiquitination	[3]
114	KAELEIQKDALEPGQ	acetylation	[1, 4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 15 15 Phosphoserine (By similarity).
 MOD_RES 60 60 Phosphotyrosine (By similarity).
 MOD_RES 66 66 Phosphoserine (By similarity).
 MOD_RES 114 114 N6-acetyllysine (By similarity).
 MOD_RES 135 135 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Glycosyltransferase; Phosphoprotein; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 180 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0002055; F:adenine binding; IDA:MGI.
 GO:0003999; F:adenine phosphoribosyltransferase activity; IDA:MGI.
 GO:0006168; P:adenine salvage; IMP:MGI.
 GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
 GO:0007625; P:grooming behavior; IGI:MGI.
 GO:0006166; P:purine ribonucleoside salvage; IMP:MGI. 

Interpro

 IPR005764; Ade_phspho_trans.
 IPR000836; PRibTrfase_dom. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00103; PUR_PYR_PR_TRANSFER 

PRINTS